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Database: UniProt
Entry: C4Z8B4_AGARV
LinkDB: C4Z8B4_AGARV
Original site: C4Z8B4_AGARV 
ID   C4Z8B4_AGARV            Unreviewed;       779 AA.
AC   C4Z8B4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   13-NOV-2019, entry version 68.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   OrderedLocusNames=EUBREC_1371 {ECO:0000313|EMBL:ACR75131.1};
OS   Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 /
OS   KCTC 5835 / VPI 0990) (Eubacterium rectale).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae.
OX   NCBI_TaxID=515619 {ECO:0000313|EMBL:ACR75131.1, ECO:0000313|Proteomes:UP000001477};
RN   [1] {ECO:0000313|EMBL:ACR75131.1, ECO:0000313|Proteomes:UP000001477}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990
RC   {ECO:0000313|Proteomes:UP000001477};
RX   PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA   Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA   Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA   Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA   Hettich R.L., Gordon J.I.;
RT   "Characterizing a model human gut microbiota composed of members of
RT   its two dominant bacterial phyla.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU362098}.
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DR   EMBL; CP001107; ACR75131.1; -; Genomic_DNA.
DR   RefSeq; WP_012742230.1; NC_012781.1.
DR   EnsemblBacteria; ACR75131; ACR75131; EUBREC_1371.
DR   GeneID; 41342041; -.
DR   KEGG; ere:EUBREC_1371; -.
DR   HOGENOM; HOG000054021; -.
DR   KO; K04759; -.
DR   OMA; PLGYDWK; -.
DR   OrthoDB; 304844at2; -.
DR   BioCyc; EREC:G149K-8759-MONOMER; -.
DR   Proteomes; UP000001477; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR007167; Fe-transptr_FeoA.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   Pfam; PF04023; FeoA; 1.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   SMART; SM00899; FeoA; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001477};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001477};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    403    424       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    467    488       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    508    531       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    543    568       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    574    594       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    632    650       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    756    778       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN      115    276       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
FT   REGION       77    108       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      335    355       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   779 AA;  85489 MW;  244930E4697F1FAE CRC64;
     MTLKELGIGQ SARILTVGGE GALRQHFLDM GVIPKAEVTV IKFAPMGDPM ELQVHGYELT
     LRLDDAAQIE VELIDSRSRK HEGPKKISNT AHPGLGEEGK YHVKGSGNPL PDGEKLTYAL
     VGNQNCGKTT LFNQLTGSNQ HVGNFPGVTV DRKDGSIKEH PDTSITDLPG IYSMSPYTNE
     EIVSRNFVLD NKPKAIINIV DATNIERNLY LTMQLLEMDI PMVIALNMMD EVTANSGSID
     VNKIEGLLGV PVVPISAAKN QGVDELVRHA IHIAKYQERP GRQDFCDEND FGGAVHRCIH
     AVSHLIEDHA KLAGVPIRFA ATKIIEGDAL ILEQLHLDEN EKEAIEHLIV QMEKERGLDR
     SAAIADMRFT FIEKICESTV VKPKESRERI RSERIDRVLT GKYTAIPCFI VIMLAVFYLT
     FNVIGAGLQW LLEQGIGALT ALTDKALTAA GVNEVLHGLV IDGIFQGVGS VLSFLPIIVT
     LFFFLSLMED SGYIARVAFF MDKLLRKIGL SGRSIVPMLI GFGCTVPAVM ATRTLPSERD
     RRMTILLTPF MSCSAKLPIY AFFVSAFFPK HGGLVMGGLY FLGIIVGILF AFIYRKTLFR
     GDAVPFVMEL PNYRMPGAKN VCQLLWEKAK DFLQKAFTVI LIATMLIWFL QSFDIHFNMV
     TDSKDSMLAA ISSVIVPIFK PLGLGDWRIC TSLISGLMAK ESVVSTLEIL FGGTVTTALT
     TLSAASLLVF SLLYSPCVAA IASIKRELGA KWAVSVVLLQ CAIAWVAAFI VRVIGLLVM
//
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