ID C4ZB83_AGARV Unreviewed; 411 AA.
AC C4ZB83;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=EUBREC_0367 {ECO:0000313|EMBL:ACR74158.1};
OS Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835
OS / VPI 0990) (Eubacterium rectale).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Agathobacter.
OX NCBI_TaxID=515619 {ECO:0000313|EMBL:ACR74158.1, ECO:0000313|Proteomes:UP000001477};
RN [1] {ECO:0000313|EMBL:ACR74158.1, ECO:0000313|Proteomes:UP000001477}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / LMG 30912 / VPI
RC 0990 {ECO:0000313|Proteomes:UP000001477};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001107; ACR74158.1; -; Genomic_DNA.
DR AlphaFoldDB; C4ZB83; -.
DR STRING; 515619.EUBREC_0367; -.
DR PaxDb; 515619-EUBREC_0367; -.
DR KEGG; ere:EUBREC_0367; -.
DR HOGENOM; CLU_000445_89_36_9; -.
DR Proteomes; UP000001477; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR032834; NatK_C.
DR PANTHER; PTHR45453; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR PANTHER; PTHR45453:SF1; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR Pfam; PF14501; HATPase_c_5; 1.
DR Pfam; PF00512; HisKA; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 214..411
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 187..214
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 411 AA; 47371 MW; DF8F9CFC1248CB9C CRC64;
MHVYTQNGEE DTVLRDDLKR VKQKLSLTFA IAIIGTCVVF GLLYYLGIDL LSYYIEAGSC
MIYYNEKPYI DEFQQYVSDN DISTTDVEQY DEWMSEHDVA FYSVQEMGKV IYNKSNVDKL
ISPAKNMYDY RFTGSYELPV QFSDIEAEVF IYTGFTEKYY IAFMIFDVGF SLMLGIVFVY
LRIRKIIAGY QTELEASQEQ EKKARQEKDE LMRNMAHDLR TPLTGVMTYV DVMKLENEAY
AENMKNLNFI SEKVLDIRTQ VDNLLDFSIA GSQRPVELDA SMDVEYIFGD YLSDVCAQLM
KSNYEVDAEG ISFKQVKVAV NMAFLTRIFS NLTDNIYKYA DNKKPVVMKT AFTKKTFSVE
IGNGVCDNKT LLKSAGIGLK SVDAMMQRMN GSMSFKREHG KFWVKLEFPI V
//
