ID C4ZIB3_THASP Unreviewed; 517 AA.
AC C4ZIB3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Tmz1t_0004 {ECO:0000313|EMBL:ACK52807.1};
OS Thauera aminoaromatica.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Rhodocyclales; Zoogloeaceae;
OC Thauera.
OX NCBI_TaxID=164330 {ECO:0000313|EMBL:ACK52807.1, ECO:0000313|Proteomes:UP000002186};
RN [1] {ECO:0000313|Proteomes:UP000002186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MZ1T {ECO:0000313|Proteomes:UP000002186};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Sayler G.S.;
RT "Complete sequence of chromosome of Thauera sp. MZ1T.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACK52807.1, ECO:0000313|Proteomes:UP000002186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MZ1T {ECO:0000313|EMBL:ACK52807.1,
RC ECO:0000313|Proteomes:UP000002186};
RX PubMed=23407619; DOI=10.4056/sigs.2696029;
RA Jiang K., Sanseverino J., Chauhan A., Lucas S., Copeland A., Lapidus A.,
RA Del Rio T.G., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D.,
RA Brettin T., Detter J.C., Han C., Chang Y.J., Larimer F., Land M.,
RA Hauser L., Kyrpides N.C., Mikhailova N., Moser S., Jegier P., Close D.,
RA Debruyn J.M., Wang Y., Layton A.C., Allen M.S., Sayler G.S.;
RT "Complete genome sequence of Thauera aminoaromatica strain MZ1T.";
RL Stand. Genomic Sci. 6:325-335(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP001281; ACK52807.1; -; Genomic_DNA.
DR RefSeq; WP_012584162.1; NC_011662.2.
DR AlphaFoldDB; C4ZIB3; -.
DR STRING; 85643.Tmz1t_0004; -.
DR REBASE; 19408; M.TspMZORF4P.
DR KEGG; tmz:Tmz1t_0004; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_4_1_4; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000002186; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000313|EMBL:ACK52807.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002186};
KW Transferase {ECO:0000313|EMBL:ACK52807.1}.
FT DOMAIN 8..119
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 144..474
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 484..514
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 517 AA; 57350 MW; 4040270694D6FF34 CRC64;
MSLDLNQLET RLWAAADQLW ANTGLKPSEF SNPVLGLIFL RYAEKRFHEA EAKLIESGLG
VSEIEKFDYQ AEGALYLPDN AHFSYLLDLA EGQDLGKAVN EAMAAVEAEN EELKGVLPRS
YGRLPNTVLV ELLRVLNGLG EVEGDAFGKI YEYFLGKFAL AEGQKGGVFY TPTSIVKLIV
EIIEPFHGKI FDPACGSGGM FVQSAQFVSR HQKRAAEELT VYGTEKANDT VKLAKMNLAV
HGLSGDIRES NTYYEDPHKA VVGNTGKFDF VMANPPFNVS GVDKERVKDD PRFPFGIPTT
DNANYLWIQH FYTALNERGR AGFVMANSAG DARGTELEIR KKLIQTGGVD VIVSVGSNFF
YTVTLPCTLW FFDRAKAKGE RKDEVLFIDA RGTYRQVSRA IRDFLPEQIE FLANIVRLWR
GEAVEIEAGS QEMLRQQFPE GGYRDIAGVC KVATLAEIEA QGWSLNPGRY VGVADRGADD
FDFAEKFEAL AEELERLNGE ADQLQEQISS QAVALLS
//
