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Database: UniProt
Entry: C4ZJY7_THASP
LinkDB: C4ZJY7_THASP
Original site: C4ZJY7_THASP 
ID   C4ZJY7_THASP            Unreviewed;       358 AA.
AC   C4ZJY7;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 64.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   OrderedLocusNames=Tmz1t_2239 {ECO:0000313|EMBL:ACK54978.1};
OS   Thauera sp. (strain MZ1T).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC   Zoogloeaceae; Thauera.
OX   NCBI_TaxID=85643 {ECO:0000313|EMBL:ACK54978.1, ECO:0000313|Proteomes:UP000002186};
RN   [1] {ECO:0000313|Proteomes:UP000002186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MZ1T {ECO:0000313|Proteomes:UP000002186};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Sayler G.S.;
RT   "Complete sequence of chromosome of Thauera sp. MZ1T.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACK54978.1, ECO:0000313|Proteomes:UP000002186}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MZ1T {ECO:0000313|EMBL:ACK54978.1,
RC   ECO:0000313|Proteomes:UP000002186};
RX   PubMed=23407619; DOI=10.4056/sigs.2696029;
RA   Jiang K., Sanseverino J., Chauhan A., Lucas S., Copeland A.,
RA   Lapidus A., Del Rio T.G., Dalin E., Tice H., Bruce D., Goodwin L.,
RA   Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Chang Y.J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N.C., Mikhailova N.,
RA   Moser S., Jegier P., Close D., Debruyn J.M., Wang Y., Layton A.C.,
RA   Allen M.S., Sayler G.S.;
RT   "Complete genome sequence of Thauera aminoaromatica strain MZ1T.";
RL   Stand. Genomic Sci. 6:325-335(2012).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP001281; ACK54978.1; -; Genomic_DNA.
DR   RefSeq; WP_004302143.1; NC_011662.2.
DR   STRING; 85643.Tmz1t_2239; -.
DR   EnsemblBacteria; ACK54978; ACK54978; Tmz1t_2239.
DR   KEGG; tmz:Tmz1t_2239; -.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   HOGENOM; HOG000220501; -.
DR   KO; K01626; -.
DR   OMA; VMENVAN; -.
DR   OrthoDB; 853329at2; -.
DR   BioCyc; TSP85643:TMZ1T_RS11075-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000002186; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002186};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002186};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:ACK54978.1}.
FT   DOMAIN       44    339       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   358 AA;  39103 MW;  3D5807C07F0C718B CRC64;
     MPTQTENLNV LAFDHMPSPD EVKARVPLTE RAAAAVVAGR KAVMDILDRK DPRVFVVVGP
     CSIHDPVAGL DYARRLKALA DEVSDVLLLV MRVYFEKPRT STGWKGYIND PFMDDSFRID
     VGMERARKFL LDVCELGLPT ATEALDPIAP QYYGDLIAWT AIGARTSESQ THREMASGLS
     TPVGFKNATD GDLEVAINAI ISAGSPHSFL GINSQGQSAV TRTRGNRYGH VVLRGGGGRP
     NYDTVSVSLA EQALAKAKLA KNIVVDCSHA NSWKKPEYQP LVMKDVMHQI REGNQSIVGL
     MIESNIEAGN QPIPADLSQL KYGCSVTDAC VDWATTEDMI RKSAAVLRDV LPKRERRA
//
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