ID C5A1Y5_THEGJ Unreviewed; 454 AA.
AC C5A1Y5;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Membrane bound protease, putative, nfeD/ClpP-family (NfeD) {ECO:0000313|EMBL:ACS34404.1};
GN Name=nfeD {ECO:0000313|EMBL:ACS34404.1};
GN OrderedLocusNames=TGAM_1902 {ECO:0000313|EMBL:ACS34404.1};
OS Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=593117 {ECO:0000313|EMBL:ACS34404.1, ECO:0000313|Proteomes:UP000001488};
RN [1] {ECO:0000313|EMBL:ACS34404.1, ECO:0000313|Proteomes:UP000001488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15229 / JCM 11827 / EJ3
RC {ECO:0000313|Proteomes:UP000001488};
RX PubMed=19558674; DOI=10.1186/gb-2009-10-6-r70;
RA Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M.,
RA Anthouard V., Forterre P., Wincker P., Confalonieri F.;
RT "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans,
RT the most radioresistant organism known amongst the Archaea.";
RL Genome Biol. 10:R70.1-R70.23(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001398; ACS34404.1; -; Genomic_DNA.
DR RefSeq; WP_015859510.1; NC_012804.1.
DR AlphaFoldDB; C5A1Y5; -.
DR STRING; 593117.TGAM_1902; -.
DR PaxDb; 593117-TGAM_1902; -.
DR GeneID; 7988306; -.
DR KEGG; tga:TGAM_1902; -.
DR PATRIC; fig|593117.10.peg.1913; -.
DR eggNOG; arCOG01910; Archaea.
DR HOGENOM; CLU_024619_1_1_2; -.
DR OrthoDB; 28112at2157; -.
DR Proteomes; UP000001488; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07020; Clp_protease_NfeD_1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR002810; NfeD-like_C.
DR InterPro; IPR002825; Pept_S49_ser-pept_pro.
DR PANTHER; PTHR33507; INNER MEMBRANE PROTEIN YBBJ; 1.
DR PANTHER; PTHR33507:SF3; INNER MEMBRANE PROTEIN YBBJ; 1.
DR Pfam; PF01957; NfeD; 1.
DR Pfam; PF01972; SDH_sah; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF141322; NfeD domain-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:ACS34404.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000313|EMBL:ACS34404.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 360..443
FT /note="NfeD-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01957"
SQ SEQUENCE 454 AA; 48909 MW; 3E3667D493DC15CE CRC64;
MIMKTRTLSR SAFIILVLML LPAVLASPNQ KTVYVAKFEG VITSYSVDQF SRYIEIAEKN
NAEALIIEID TPGGSGQAMQ EIIQRIKESK VPVIIYVYPP GAIAASAGTY IALGSHLIAM
APSTSIGACE PIMGYASNGS IIKAPAKVRN FYVAYIKSLA EASGRNVTAA ERFITEDLSL
TPEEALRAHV IEVIANDVPD LLKKANGMKT KIPVKGKGYV TLNFTNARIV SIEPSFKDEV
VRYISDPTIA YVLINIGILG LIFGFLTPGW HVPETVGAIL LVLGIIGLGY FGYNAAGLVL
IILAVIFFIA EALTPTFGLF TVAGAITMIL GGILLFGGGN EYLIQRSTFS TLRAVIIAIA
VMLALFFAFG VSAVIRDRKR KAQTGKEEMI GEVGRVVQEL NPEGMVKIRG ELWKAESKTG
ERIGVGEKVR VVEVRGLTLI VVPEGVSPDE KKEV
//
