ID C5AF46_BURGB Unreviewed; 327 AA.
AC C5AF46;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=DNA-3-methyladenine glycosylase II {ECO:0000256|ARBA:ARBA00012000};
DE EC=3.2.2.21 {ECO:0000256|ARBA:ARBA00012000};
GN OrderedLocusNames=bglu_1g34190 {ECO:0000313|EMBL:ACR30481.1};
OS Burkholderia glumae (strain BGR1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=626418 {ECO:0000313|EMBL:ACR30481.1, ECO:0000313|Proteomes:UP000002187};
RN [1] {ECO:0000313|EMBL:ACR30481.1, ECO:0000313|Proteomes:UP000002187}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGR1 {ECO:0000313|EMBL:ACR30481.1,
RC ECO:0000313|Proteomes:UP000002187};
RX PubMed=19329631; DOI=10.1128/JB.00349-09;
RA Lim J., Lee T.H., Nahm B.H., Choi Y.D., Kim M., Hwang I.;
RT "Complete genome sequence of Burkholderia glumae BGR1.";
RL J. Bacteriol. 191:3758-3759(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-
CC methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00000086};
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DR EMBL; CP001503; ACR30481.1; -; Genomic_DNA.
DR RefSeq; WP_015877332.1; NC_012724.2.
DR AlphaFoldDB; C5AF46; -.
DR STRING; 626418.bglu_1g34190; -.
DR KEGG; bgl:bglu_1g34190; -.
DR PATRIC; fig|626418.3.peg.6381; -.
DR eggNOG; COG0122; Bacteria.
DR HOGENOM; CLU_000445_72_3_4; -.
DR Proteomes; UP000002187; Chromosome 1.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR CDD; cd00056; ENDO3c; 1.
DR Gene3D; 3.30.310.20; DNA-3-methyladenine glycosylase AlkA, N-terminal domain; 1.
DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR InterPro; IPR010316; AlkA_N.
DR InterPro; IPR037046; AlkA_N_sf.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR003265; HhH-GPD_domain.
DR InterPro; IPR023170; HhH_base_excis_C.
DR PANTHER; PTHR43003; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR PANTHER; PTHR43003:SF13; DNA-3-METHYLADENINE GLYCOSYLASE 2; 1.
DR Pfam; PF06029; AlkA_N; 1.
DR Pfam; PF00730; HhH-GPD; 1.
DR SMART; SM01009; AlkA_N; 1.
DR SMART; SM00478; ENDO3c; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
DR SUPFAM; SSF55945; TATA-box binding protein-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002187}.
FT DOMAIN 30..148
FT /note="DNA-3-methyladenine glycosylase AlkA N-terminal"
FT /evidence="ECO:0000259|SMART:SM01009"
FT DOMAIN 158..317
FT /note="HhH-GPD"
FT /evidence="ECO:0000259|SMART:SM00478"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 34056 MW; 2E06BAA1AD077BBB CRC64;
MTRAAASAGR GATAPGESRG DGDAAAARVE FALPFKSPYD WPRVLRFLGG RASPGVETAA
DGAYLRAIDY RGASGVLTVR RHPRRRCLVA AIDGEAALQA DAALVARLSA MFDVGTDPLA
LGAHLSADAW FAPLVAAAPG LRVPGAWSAF ELVVRAIVGQ QISVKAATTI IGRLVRAVGE
PLATPPHAAV GWRFPEPAAL AAADLAGIGM PGKRLAALQG VARAVAAGEV PIDGTAADLA
TRRAALLALP GIGPWTVEYI AMRAWRDADA WPATDLVLMQ AIAARDPALA RPASQRLRSD
AWRPWRAYAA MHLWNEIADR LGAARGG
//
