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Database: UniProt
Entry: C5AMJ9_BURGB
LinkDB: C5AMJ9_BURGB
Original site: C5AMJ9_BURGB 
ID   C5AMJ9_BURGB            Unreviewed;       321 AA.
AC   C5AMJ9;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   RecName: Full=L-carnitine dehydrogenase {ECO:0000256|HAMAP-Rule:MF_02129};
DE            Short=CDH {ECO:0000256|HAMAP-Rule:MF_02129};
DE            Short=L-CDH {ECO:0000256|HAMAP-Rule:MF_02129};
DE            EC=1.1.1.108 {ECO:0000256|HAMAP-Rule:MF_02129};
GN   Name=lcdH {ECO:0000256|HAMAP-Rule:MF_02129};
GN   OrderedLocusNames=bglu_2g06130 {ECO:0000313|EMBL:ACR31050.1};
OS   Burkholderia glumae (strain BGR1).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=626418 {ECO:0000313|EMBL:ACR31050.1, ECO:0000313|Proteomes:UP000002187};
RN   [1] {ECO:0000313|EMBL:ACR31050.1, ECO:0000313|Proteomes:UP000002187}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGR1 {ECO:0000313|EMBL:ACR31050.1,
RC   ECO:0000313|Proteomes:UP000002187};
RX   PubMed=19329631; DOI=10.1128/JB.00349-09;
RA   Lim J., Lee T.H., Nahm B.H., Choi Y.D., Kim M., Hwang I.;
RT   "Complete genome sequence of Burkholderia glumae BGR1.";
RL   J. Bacteriol. 191:3758-3759(2009).
CC   -!- FUNCTION: Catalyzes the NAD(+)-dependent oxidation of L-carnitine
CC       to 3-dehydrocarnitine. {ECO:0000256|HAMAP-Rule:MF_02129}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH;
CC         Xref=Rhea:RHEA:19265, ChEBI:CHEBI:15378, ChEBI:CHEBI:17126,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57885, ChEBI:CHEBI:57945;
CC         EC=1.1.1.108; Evidence={ECO:0000256|HAMAP-Rule:MF_02129};
CC   -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC       {ECO:0000256|HAMAP-Rule:MF_02129}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_02129}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02129}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       L-carnitine dehydrogenase subfamily. {ECO:0000256|HAMAP-
CC       Rule:MF_02129}.
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DR   EMBL; CP001504; ACR31050.1; -; Genomic_DNA.
DR   RefSeq; WP_012733445.1; NC_012721.2.
DR   STRING; 626418.bglu_2g06130; -.
DR   EnsemblBacteria; ACR31050; ACR31050; bglu_2g06130.
DR   KEGG; bgl:bglu_2g06130; -.
DR   PATRIC; fig|626418.3.peg.853; -.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000141499; -.
DR   KO; K17735; -.
DR   OMA; KFLALHF; -.
DR   OrthoDB; 862072at2; -.
DR   UniPathway; UPA00117; -.
DR   Proteomes; UP000002187; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0047728; F:carnitine 3-dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042413; P:carnitine catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   HAMAP; MF_02129; L_carnitine_dehydrog; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR026578; L-carnitine_dehydrogenase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002187};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02129};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_02129};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_02129};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002187}.
FT   DOMAIN       11    184       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      188    256       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   NP_BIND      14     19       NAD. {ECO:0000256|HAMAP-Rule:MF_02129}.
SQ   SEQUENCE   321 AA;  34630 MW;  3AD52181B94F4472 CRC64;
     MTLLTDIRTF AVIGTGVTGS GWAARALANG LDVVVWDPAE GAESQLRANL ANAWPALERA
     GLKPGAAPER LRFARTVEAC VADADFIQES APEREALKLD LHERISRAAR PGAIIASSTS
     GLLPTGFYAR ATHPERCVVG HPFNPVYLLP LVEVLGGERT SAEAVDAAIA IYAGLGMRPL
     KVRKEVPGFI ADRLLEALWR EALHLVNDGV ATTGEIDDAI RFGAGIRWSF MGTFLTYTLA
     GGEPGMRHFM KQFGPALALP WTRLAAPALS DALIDRVVDG TARQQGERSI KALERYRDDC
     ITEVIAAVAR VKARHGMRDE D
//
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