ID   C5ATX5_METEA            Unreviewed;       323 AA.
AC   C5ATX5;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=UDP-glucose 4-epimerase {ECO:0000313|EMBL:ACS42674.1};
DE            EC=5.1.3.2 {ECO:0000313|EMBL:ACS42674.1};
GN   OrderedLocusNames=MexAM1_META1p5070 {ECO:0000313|EMBL:ACS42674.1};
OS   Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB
OS   9133 / AM1) (Methylobacterium extorquens).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=272630 {ECO:0000313|EMBL:ACS42674.1, ECO:0000313|Proteomes:UP000009081};
RN   [1] {ECO:0000313|EMBL:ACS42674.1, ECO:0000313|Proteomes:UP000009081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
RC   {ECO:0000313|Proteomes:UP000009081};
RX   PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA   Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA   Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA   Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA   Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA   Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA   Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA   Lidstrom M.E.;
RT   "Methylobacterium genome sequences: a reference blueprint to investigate
RT   microbial metabolism of C1 compounds from natural and industrial sources.";
RL   PLoS ONE 4:E5584-E5584(2009).
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00007637}.
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DR   EMBL; CP001510; ACS42674.1; -; Genomic_DNA.
DR   RefSeq; WP_015857589.1; NC_012808.1.
DR   AlphaFoldDB; C5ATX5; -.
DR   STRING; 272630.MexAM1_META1p5070; -.
DR   KEGG; mea:Mex_1p5070; -.
DR   eggNOG; COG0451; Bacteria.
DR   HOGENOM; CLU_007383_1_7_5; -.
DR   OrthoDB; 9807795at2; -.
DR   Proteomes; UP000009081; Chromosome.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000313|EMBL:ACS42674.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009081}.
FT   DOMAIN          5..244
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   323 AA;  34677 MW;  A636BB7A058BB63B CRC64;
     MSRLAVTGAG GFIGAHLTRA LLAEGHEVVA IDNYIRGQAS RLANAQGAIE RVTLDVRDKD
     ALVESLRGVE CVFHLAAVNG TENFYTQPQL VLDVGVRGAL AVSEGCIEAG VPDLVVASSA
     EVYQTPRVVP TDETIEMVIP DSLSPRYSYG GSKLISELIA FNYCRDKLRK VQVFRPHNIY
     GPDMGWKHVV PQLIEKIVAA GDGGSITLQG DGSETRAFCY VSDVVDGIVR MWRDGASMNV
     YHIGSMEEVA IRDLARITAE ALGTRVDLIA GPAAAGATPR RCPDIGKMQA IGYAPSVSLV
     QGIERTVAWY RENPAPTDSN PLL
//