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Database: UniProt
Entry: C5B8X5_EDWI9
LinkDB: C5B8X5_EDWI9
Original site: C5B8X5_EDWI9 
ID   C5B8X5_EDWI9            Unreviewed;       748 AA.
AC   C5B8X5;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 93.
DE   RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE   AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE   AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE   AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN   OrderedLocusNames=NT01EI_3025 {ECO:0000313|EMBL:ACR70178.1};
OS   Edwardsiella ictaluri (strain 93-146).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Hafniaceae; Edwardsiella.
OX   NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR70178.1, ECO:0000313|Proteomes:UP000001485};
RN   [1] {ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT   "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACR70178.1, ECO:0000313|Proteomes:UP000001485}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-146 {ECO:0000313|EMBL:ACR70178.1,
RC   ECO:0000313|Proteomes:UP000001485};
RX   PubMed=22247535; DOI=10.1128/JB.06522-11;
RA   Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA   Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA   Lawrence M.L.;
RT   "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated with
RT   a Natural Channel Catfish Outbreak of Enteric Septicemia of Catfish.";
RL   J. Bacteriol. 194:740-741(2012).
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
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DR   EMBL; CP001600; ACR70178.1; -; Genomic_DNA.
DR   RefSeq; WP_015872268.1; NC_012779.2.
DR   AlphaFoldDB; C5B8X5; -.
DR   STRING; 67780.B6E78_06995; -.
DR   GeneID; 69539900; -.
DR   KEGG; eic:NT01EI_3025; -.
DR   PATRIC; fig|634503.3.peg.2705; -.
DR   HOGENOM; CLU_012300_3_0_6; -.
DR   OMA; TEIGHNC; -.
DR   OrthoDB; 9805041at2; -.
DR   Proteomes; UP000001485; Chromosome.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF19296; RelA_AH_RIS; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
FT   DOMAIN          55..160
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
FT   DOMAIN          403..464
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          667..742
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   748 AA;  84363 MW;  37B8D83DDCFD44F0 CRC64;
     MVAVRSAHLN TAGEFVPEQW VASLNLSNSE SCERLTATWR YCQEKTAGNA AAPLLLWRGV
     EMVEILSTLS MDNDSMRAAL LFPLVDGAVI DDARVREDFG LGIADLVRGV LEMDAIRQLK
     ATQDGAVGSE QVDNIRRMLL AIVEDFRCVV IKLAERIAHL REVKDAPEEE RVLAAKESFN
     IYAPLANRLG IGQLKWELED FCFRYLHPEE YKRIAKLLHE RRIDREQFID DFVRDLRRAM
     AEEGIKADIY GRPKHIYSIW RKMQKKSLAF DELFDVRAVR VVVDRLQDCY AALGIVHTHY
     RHLPSEFDDY VANPKPNGYQ SIHTVVLGPH GKTLEIQIRT RQMHEDAELG VAAHWKYKEG
     PQAGGRSGYD NRIAWLRKLL AWQEEMADSG EMIDEVRSQV LDDRVYVFTP KGDVIDLPAG
     STPLDFAYHI HSDVGHRCIG AKIGGRIVPF TYQLQMGDQV DIITQKQPNP SRDWLNPNLG
     YVTTSRGRAK IHNWFRKLDR DKNIQAGRQI LDDELARLGI SLKEAEKLLL PRYNVHTLDE
     VLAAIGGGDI RLNQMVNFLQ GKINKPSAEE ADREALKQLT QKGQSSVRSD KSSGRVVVEG
     VGNLMHHIAR CCQPIPGDEI VGFITQGRGI SIHRADCDQL DELRRHAPER IIDAVWGESY
     SSGYSLVVRV TANDRSGLLR DITTILANEK VNVLGVASRS DTRQQMATID MEIEIYNLQV
     LGRVLAKLNQ LPDVLDARRL NGGRGGAE
//
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