ID C5B8X5_EDWI9 Unreviewed; 748 AA.
AC C5B8X5;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 93.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN OrderedLocusNames=NT01EI_3025 {ECO:0000313|EMBL:ACR70178.1};
OS Edwardsiella ictaluri (strain 93-146).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Hafniaceae; Edwardsiella.
OX NCBI_TaxID=634503 {ECO:0000313|EMBL:ACR70178.1, ECO:0000313|Proteomes:UP000001485};
RN [1] {ECO:0000313|Proteomes:UP000001485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-146 {ECO:0000313|Proteomes:UP000001485};
RA Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA Schuster S.C., Gipson J., Zaitshik J., Landry C., Lawrence M.L.;
RT "Complete genome sequence of Edwardsiella ictaluri 93-146.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACR70178.1, ECO:0000313|Proteomes:UP000001485}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-146 {ECO:0000313|EMBL:ACR70178.1,
RC ECO:0000313|Proteomes:UP000001485};
RX PubMed=22247535; DOI=10.1128/JB.06522-11;
RA Williams M.L., Gillaspy A.F., Dyer D.W., Thune R.L., Waldbieser G.C.,
RA Schuster S.C., Gipson J., Zaitshik J., Landry C., Banes M.M.,
RA Lawrence M.L.;
RT "Genome Sequence of Edwardsiella ictaluri 93-146, a Strain Associated with
RT a Natural Channel Catfish Outbreak of Enteric Septicemia of Catfish.";
RL J. Bacteriol. 194:740-741(2012).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; CP001600; ACR70178.1; -; Genomic_DNA.
DR RefSeq; WP_015872268.1; NC_012779.2.
DR AlphaFoldDB; C5B8X5; -.
DR STRING; 67780.B6E78_06995; -.
DR GeneID; 69539900; -.
DR KEGG; eic:NT01EI_3025; -.
DR PATRIC; fig|634503.3.peg.2705; -.
DR HOGENOM; CLU_012300_3_0_6; -.
DR OMA; TEIGHNC; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000001485; Chromosome.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
FT DOMAIN 55..160
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 403..464
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 667..742
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 748 AA; 84363 MW; 37B8D83DDCFD44F0 CRC64;
MVAVRSAHLN TAGEFVPEQW VASLNLSNSE SCERLTATWR YCQEKTAGNA AAPLLLWRGV
EMVEILSTLS MDNDSMRAAL LFPLVDGAVI DDARVREDFG LGIADLVRGV LEMDAIRQLK
ATQDGAVGSE QVDNIRRMLL AIVEDFRCVV IKLAERIAHL REVKDAPEEE RVLAAKESFN
IYAPLANRLG IGQLKWELED FCFRYLHPEE YKRIAKLLHE RRIDREQFID DFVRDLRRAM
AEEGIKADIY GRPKHIYSIW RKMQKKSLAF DELFDVRAVR VVVDRLQDCY AALGIVHTHY
RHLPSEFDDY VANPKPNGYQ SIHTVVLGPH GKTLEIQIRT RQMHEDAELG VAAHWKYKEG
PQAGGRSGYD NRIAWLRKLL AWQEEMADSG EMIDEVRSQV LDDRVYVFTP KGDVIDLPAG
STPLDFAYHI HSDVGHRCIG AKIGGRIVPF TYQLQMGDQV DIITQKQPNP SRDWLNPNLG
YVTTSRGRAK IHNWFRKLDR DKNIQAGRQI LDDELARLGI SLKEAEKLLL PRYNVHTLDE
VLAAIGGGDI RLNQMVNFLQ GKINKPSAEE ADREALKQLT QKGQSSVRSD KSSGRVVVEG
VGNLMHHIAR CCQPIPGDEI VGFITQGRGI SIHRADCDQL DELRRHAPER IIDAVWGESY
SSGYSLVVRV TANDRSGLLR DITTILANEK VNVLGVASRS DTRQQMATID MEIEIYNLQV
LGRVLAKLNQ LPDVLDARRL NGGRGGAE
//