GenomeNet

Database: UniProt
Entry: C5BWS3
LinkDB: C5BWS3
Original site: C5BWS3 
ID   IF2_BEUC1               Reviewed;         956 AA.
AC   C5BWS3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Translation initiation factor IF-2 {ECO:0000255|HAMAP-Rule:MF_00100};
GN   Name=infB {ECO:0000255|HAMAP-Rule:MF_00100}; OrderedLocusNames=Bcav_2489;
OS   Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Beutenbergiaceae;
OC   Beutenbergia.
OX   NCBI_TaxID=471853;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432;
RX   PubMed=21304633; DOI=10.4056/sigs.1162;
RA   Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA   Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D.,
RA   Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA   Pati A., Chen A., Palaniappan K., Hauser L., Chang Y.J., Jefferies C.C.,
RA   Saunders E., Brettin T., Detter J.C., Han C., Chain P., Bristow J.,
RA   Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA   Lapidus A.;
RT   "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT   0122).";
RL   Stand. Genomic Sci. 1:21-28(2009).
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00100}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001618; ACQ80739.1; -; Genomic_DNA.
DR   RefSeq; WP_015882979.1; NC_012669.1.
DR   AlphaFoldDB; C5BWS3; -.
DR   SMR; C5BWS3; -.
DR   STRING; 471853.Bcav_2489; -.
DR   KEGG; bcv:Bcav_2489; -.
DR   eggNOG; COG0532; Bacteria.
DR   HOGENOM; CLU_006301_9_1_11; -.
DR   OrthoDB; 9811804at2; -.
DR   Proteomes; UP000007962; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd01887; IF2_eIF5B; 1.
DR   CDD; cd03702; IF2_mtIF2_II; 1.
DR   CDD; cd03692; mtIF2_IVc; 1.
DR   Gene3D; 1.10.10.2480; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR   HAMAP; MF_00100_B; IF_2_B; 1.
DR   InterPro; IPR044145; IF2_II.
DR   InterPro; IPR006847; IF2_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   NCBIfam; TIGR00487; IF-2; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   Pfam; PF04760; IF2_N; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 2.
DR   PROSITE; PS51722; G_TR_2; 1.
DR   PROSITE; PS01176; IF2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTP-binding; Initiation factor; Nucleotide-binding;
KW   Protein biosynthesis; Reference proteome.
FT   CHAIN           1..956
FT                   /note="Translation initiation factor IF-2"
FT                   /id="PRO_1000202764"
FT   DOMAIN          448..619
FT                   /note="tr-type G"
FT   REGION          50..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          457..464
FT                   /note="G1"
FT                   /evidence="ECO:0000250"
FT   REGION          482..486
FT                   /note="G2"
FT                   /evidence="ECO:0000250"
FT   REGION          507..510
FT                   /note="G3"
FT                   /evidence="ECO:0000250"
FT   REGION          561..564
FT                   /note="G4"
FT                   /evidence="ECO:0000250"
FT   REGION          597..599
FT                   /note="G5"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        66..118
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         457..464
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         507..511
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
FT   BINDING         561..564
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00100"
SQ   SEQUENCE   956 AA;  98104 MW;  33FBB1EEA1CA94E3 CRC64;
     MAKVRVHELA RELGVDSKTV LAKLNELGEF VKSASSTIEA PVVRRLRESF PADSGGAANG
     APAAPKPARA PKPAPKAAPA PPVEEAPAEP APPAAPEVVA APEAPVAAPE PPAPSREAEV
     PEAPAAERPA AQARPATPGP RPAPRAAEKP ADTRTPRPGN NPFASSQGMP RPGGQGGPRP
     GGPRPSGGGG PRPGNNPFAP SQGMPRPGGS GAAGPRPGGT GAAGPRPGGS GQGGSRPSPG
     MMPGRSAVGR PGAPARGGSG GPGGGRGGPG GGRGGGGGFG GAPGRGGPGG APGGGGGFSG
     GGRSGRGGRG GTQGAFGRAG GKPVRARKSR RAKRQEFEQM SAPSIGGVQV PRGDGTTVVR
     IRRGASLSDF ADRIDANPAS LVTVLFHLGE MATVTQALDA GTFEALGAEL GYVIEIVSPE
     DEERELLGSF DIDLDAEAAA ESDEDLEARP PVVTVMGHVD HGKTRLLDAI RSTDVVAGEA
     GGITQHIGAY QVHVTHEDAD RAVTFLDTPG HEAFTAMRAR GADVTDIAIL VVAADDGVMP
     QTIEALNHAQ AANVPIVVAV NKVDKEGANP DKVMQQLTEY NLVAEAYGGD TMFVNVSAKN
     GTGIDELLEA VLLTADAALD LRANPNKDAR GVAIEANLDK GRGAVATVLV QSGTLTVGDS
     IVAGTAYGRV RAMFDENGDN LSEATPSRPV QVLGLTSVPR AGDSFLVAPD DRTARQIADK
     RDAAERAATL AKRRKRISLE DFTQALEQGK VSTLNLVLKG DVSGAVEALE DALLQLDVGA
     EVDLRIIHRG VGGITQNDVN LATVDNAIII GFNVRPDVRV AELADREGVD IRYYSVIYAA
     IEDVENSLKG MLKPEFEEVQ LGTAEVLQVF RSSKFGNIAG SRVRSGLIRR GASARVLRDS
     VVIGDNLSIG SLRREKDDVT EVRDGFECGI GLGSFNDLRE GDVIETFEVR EKERAS
//
DBGET integrated database retrieval system