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Database: UniProt
Entry: C5BXU5_BEUC1
LinkDB: C5BXU5_BEUC1
Original site: C5BXU5_BEUC1 
ID   C5BXU5_BEUC1            Unreviewed;       357 AA.
AC   C5BXU5;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   OrderedLocusNames=Bcav_0576 {ECO:0000313|EMBL:ACQ78839.1};
OS   Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC   Bacteria; Actinobacteria; Micrococcales; Beutenbergiaceae;
OC   Beutenbergia.
OX   NCBI_TaxID=471853 {ECO:0000313|EMBL:ACQ78839.1, ECO:0000313|Proteomes:UP000007962};
RN   [1] {ECO:0000313|EMBL:ACQ78839.1, ECO:0000313|Proteomes:UP000007962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432
RC   {ECO:0000313|Proteomes:UP000007962};
RX   PubMed=21304633; DOI=10.4056/sigs.1162;
RA   Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA   Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M.,
RA   Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavromatis K.,
RA   Ovchinnikova G., Pati A., Chen A., Palaniappan K., Hauser L.,
RA   Chang Y.J., Jefferies C.C., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Chain P., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT   0122).";
RL   Stand. Genomic Sci. 1:21-28(2009).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP001618; ACQ78839.1; -; Genomic_DNA.
DR   RefSeq; WP_012725619.1; NC_012669.1.
DR   STRING; 471853.Bcav_0576; -.
DR   EnsemblBacteria; ACQ78839; ACQ78839; Bcav_0576.
DR   KEGG; bcv:Bcav_0576; -.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   HOGENOM; HOG000220501; -.
DR   KO; K01626; -.
DR   OMA; YDINTGL; -.
DR   OrthoDB; 853329at2; -.
DR   BioCyc; BCAV471853:G1GET-580-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000007962; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007962};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007962};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:ACQ78839.1}.
FT   DOMAIN       49    343       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   357 AA;  37069 MW;  01120D4210B08C5B CRC64;
     MTTVAAAPRT NDLRVRALEL LPTPAAIRTE APLDDDGAAL VASSRRGASD ILRGADDRLL
     VVVGPCSIHD PEAALAYAAR LAPLRERFAD SLEVVMRVYF EKPRTTLGWK GLINDPGLDG
     SHDVPRGLRL ARRVLLDVVA AGLPAATEFL EPTTPQYVAD AVSWGAIGAR TPESQVHRQL
     ASGLSMPIGF KNATDGDVQA AIDGCVAAAA EHTFLGIDDD GRASAVATTG NPDGHVVLRG
     GRSGPNFDAA SVAAALDLIG AAGLPRRLVV DASHGNSGKD HVRQAGVVRE LAQRIGAGER
     GIAGVMIESF LVPGRQEPAP TGLVFGQSVT DACVGWDETE ELLAALAVAS ASRRLSA
//
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