ID C5BYN2_BEUC1 Unreviewed; 501 AA.
AC C5BYN2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN OrderedLocusNames=Bcav_0729 {ECO:0000313|EMBL:ACQ78990.1};
OS Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Beutenbergiaceae;
OC Beutenbergia.
OX NCBI_TaxID=471853 {ECO:0000313|EMBL:ACQ78990.1, ECO:0000313|Proteomes:UP000007962};
RN [1] {ECO:0000313|EMBL:ACQ78990.1, ECO:0000313|Proteomes:UP000007962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432
RC {ECO:0000313|Proteomes:UP000007962};
RX PubMed=21304633; DOI=10.4056/sigs.1162;
RA Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D.,
RA Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Hauser L., Chang Y.J., Jefferies C.C.,
RA Saunders E., Brettin T., Detter J.C., Han C., Chain P., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT 0122).";
RL Stand. Genomic Sci. 1:21-28(2009).
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DR EMBL; CP001618; ACQ78990.1; -; Genomic_DNA.
DR RefSeq; WP_012725770.1; NC_012669.1.
DR AlphaFoldDB; C5BYN2; -.
DR STRING; 471853.Bcav_0729; -.
DR KEGG; bcv:Bcav_0729; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_10_11; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000007962; Chromosome.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ACQ78990.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007962}.
FT DOMAIN 17..477
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 501 AA; 53153 MW; AFF3E5886E132D69 CRC64;
MTTIGHWIDG KPYSPAAEKT SPVYDPARGE VVAQLAHATP GEVDEAVGAA SRAFEDWSQV
SLAKRSSILF GFRELLVAHT DELARIVSRE HGKVISDAKG EIGRGLEVVE FASGIPQLLK
GEYSPQAATG IDVYSFRQPL GVAVGITPFN FPAMVPLWMA PLAIACGNTF VLKPSERDPS
ASLFLAQLWA DAGLPDGVFN VVQGDKVAVD ALLTHDDVAA VSFVGSTPIA RYIHATATEH
GKRVQALGGA KNHAVVLGDA DLDNAAENLT AAAFGAAGER CMAISVAVVE DSVADALVER
LATKARAVRV RPGSDPDADM GPVITPAAKE RIERLIGSAE DDGATLVVDG RGHVVDGHED
GFFVGPTVID HVQPEHEAYR EEIFGPVIDV VRVTGLEEAV DVINTNPYGN GTAIFTSSGE
AARTFQRDVT VGMIGINVPI PVPVAYHSFG GWKDSLFGSS HIYGPEGVAF YTQAKVVTQR
WPRTRELADR ASFHFSGDST K
//
