ID C5C3C8_BEUC1 Unreviewed; 1110 AA.
AC C5C3C8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=Bcav_1571 {ECO:0000313|EMBL:ACQ79827.1};
OS Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Beutenbergiaceae;
OC Beutenbergia.
OX NCBI_TaxID=471853 {ECO:0000313|EMBL:ACQ79827.1, ECO:0000313|Proteomes:UP000007962};
RN [1] {ECO:0000313|EMBL:ACQ79827.1, ECO:0000313|Proteomes:UP000007962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432
RC {ECO:0000313|Proteomes:UP000007962};
RX PubMed=21304633; DOI=10.4056/sigs.1162;
RA Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D.,
RA Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Hauser L., Chang Y.J., Jefferies C.C.,
RA Saunders E., Brettin T., Detter J.C., Han C., Chain P., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT 0122).";
RL Stand. Genomic Sci. 1:21-28(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP001618; ACQ79827.1; -; Genomic_DNA.
DR RefSeq; WP_015882067.1; NC_012669.1.
DR AlphaFoldDB; C5C3C8; -.
DR STRING; 471853.Bcav_1571; -.
DR KEGG; bcv:Bcav_1571; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_1_1_11; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000007962; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000007962}.
FT DOMAIN 3..441
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 463..745
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 919..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1110 AA; 118715 MW; 2D4679EBE7160BB2 CRC64;
MTLVDDAARS RIATDTSSSL FVEAGAGSGK TRSLVERVGT LVMDDGVPLA QIAAITFTEK
AGAELRDRLR GEFERVWRRA RPGGPQEDPA RSSLAERALE DLDGAAIGTL HSFAQRILAR
HPVEAGLPPL IEVSDEVASG VAFDERWSVL QRELLDDEEM APRLLLAMAA GVTFDHLRSL
ARAFGADWDL IEGHVLRGAS NDSALPDAAP LVDEAQALAA RAAECTDPDD KLLTRLSEIR
AWAQVLAAAD GDPRRTYAAL VALGEPRFGR VGRKTSWPDV DAVRAACTAL VEHVSAAAAA
FADAAVRPLA RWIAARVVRD ARARAAEGAL EFHDLLVLAR DLLRTREDVR SSLQAAYPRL
LLDEFQDTDP IQVELAVRIA AGAEGGAGDW HDVRVPPGSL FVVGDPKQSI YRFRRADIRT
FLDVRTWLGD VCSLTTNFRS AAPVLAWVNA TFGELIQPVD GAQPAYEPLD AVRPPVGVGP
AVTVLGAQPH QDLPRASAAL LREREAADVA AVLLRAAGQG WTVHDPRGGE ERELRWGDVA
VLVPARTSLP FLVEALDAAG IPYRAESSSL VYSATEVRAL MAAARAIADP GDQFSVVTAL
RSQVYGCGDD DLWSWKRDGG SFHLLAPADE DRADHPVAQG LAHLRTVHRW ARWATPSEVL
ARVAADRRMF EVPADAPAHA RDVWRRLRFV LDQARAWSEV SHGGLRAYLA WAARQADESS
RVAEAILPET DVDAVRIMTI HAAKGLEFPL VVLSGLTSQQ RRASGVRLLW TDDGYAVRLR
QSVQTNDFTA AAPLDEQMDD HERRRLLYVG ATRARDHLVV SLHRGPTAAA THARLLADAG
GSGAGAHAFT AADDGAARPE RAAAPAAPDH AAWAGRLEAA RAASRRVATH SASGLEGTEP
EVVFAHSATG RANAGDAVVD PGGGEGDALP GSAKGPRDLA LPPWSKGRYG TAIGRAVHGV
LQAVDLRVQL ADAGELDAAV EAQARVEGVL EFADVVADLA LSALASPLVQ DAARREHWAE
TFVATLEPDG RVLEGVVDLL VRDADGAVTI VDYKTDAVPE AALGVRTEFY APQLRAYARA
LRDAGADVRR AVLLFLAPDG AVEREVTLGL
//
