ID C5CCD8_MICLC Unreviewed; 867 AA.
AC C5CCD8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=ComEC family competence protein {ECO:0000313|EMBL:SQG49708.1};
DE SubName: Full=ComEC/Rec2-related protein {ECO:0000313|EMBL:ACS30750.1};
GN OrderedLocusNames=Mlut_12450 {ECO:0000313|EMBL:ACS30750.1};
GN ORFNames=NCTC2665_02266 {ECO:0000313|EMBL:SQG49708.1};
OS Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 /
OS NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Micrococcus.
OX NCBI_TaxID=465515 {ECO:0000313|EMBL:ACS30750.1, ECO:0000313|Proteomes:UP000000738};
RN [1] {ECO:0000313|EMBL:ACS30750.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NCTC 2665 {ECO:0000313|EMBL:ACS30750.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Lowry S., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Young M., Greenblatt C.;
RT "Complete sequence of Micrococcus luteus NCTC 2665.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 /
RC NCTC 2665 / VKM Ac-2230 {ECO:0000313|Proteomes:UP000000738};
RX PubMed=19948807; DOI=10.1128/JB.01254-09;
RA Young M., Artsatbanov V., Beller H.R., Chandra G., Chater K.F., Dover L.G.,
RA Goh E.B., Kahan T., Kaprelyants A.S., Kyrpides N., Lapidus A., Lowry S.R.,
RA Lykidis A., Mahillon J., Markowitz V., Mavromatis K., Mukamolova G.V.,
RA Oren A., Rokem J.S., Smith M.C., Young D.I., Greenblatt C.L.;
RT "Genome sequence of the Fleming strain of Micrococcus luteus, a simple
RT free-living actinobacterium.";
RL J. Bacteriol. 192:841-860(2010).
RN [3] {ECO:0000313|EMBL:SQG49708.1, ECO:0000313|Proteomes:UP000248985}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC2665 {ECO:0000313|EMBL:SQG49708.1,
RC ECO:0000313|Proteomes:UP000248985};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001628; ACS30750.1; -; Genomic_DNA.
DR EMBL; LS483396; SQG49708.1; -; Genomic_DNA.
DR RefSeq; WP_012750889.1; NC_012803.1.
DR AlphaFoldDB; C5CCD8; -.
DR STRING; 465515.Mlut_12450; -.
DR EnsemblBacteria; ACS30750; ACS30750; Mlut_12450.
DR KEGG; mlu:Mlut_12450; -.
DR PATRIC; fig|465515.4.peg.1186; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR HOGENOM; CLU_010363_4_0_11; -.
DR Proteomes; UP000000738; Chromosome.
DR Proteomes; UP000248985; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0017001; P:antibiotic catabolic process; IEA:InterPro.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001018; Beta-lactamase_class-B_CS.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR PROSITE; PS00743; BETA_LACTAMASE_B_1; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000738};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 481..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 605..781
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT REGION 167..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 85971 MW; 515C0463924B0E07 CRC64;
MVNPAPGPPS DPVDRRARRR EVPGPLDARW VPALLACLTL GILGVGWDAP ARSAAALTGL
AVAAAAVLGA ARSNGRIRGV ATATALAGVA AALMLQHSAG PAAAAEGSGW TGAVHAGSPL
RLELTLDGPA TRSEAAFGPR WSVPVRVETF GNPPRATEAP VTARLTGAGP PPETIAAPSD
GTAAPGGGPG SRVCVVARPS RSGSTVFLAA AAVPQPGPCP GGADAGGGAT DGDPGPPRRE
ALRAAFRHSA EDMVGAAPEL IPGLVLGDRS AQGAALDDAM KASGLSHLSA VSGANVAMIL
GAVAITLRCA RVHRAVVLSA GLAVLGVFVV VVGPEPSVLR AAVMGALGAL AVFFGRARQA
FGLLTVGGTA LLVAVPALAV EPAFHLSLAA TAGIVLGGAP LDRALHAGLG RVMPDVVARW
LSASLAVTVA AHLACQPIIL AMTGEVSAYA VPANLLAAPA VPPVTVLGTL AAALALPAPG
IAAALVAVIQ WPAAWIGWVA HTSASLPGAL RPWPAGALGA GLGVLLVAAT LLGFAAVLLL
ERRRTAPVRR VGRSAPRTRE RLPALVVLAA ALAAATTGAV GAVLVPRASG AAPPDWAVAF
CDVGQGDMAV FRSGPRAGVV VDVGPEPGLA RRCLDDLDVD RVDAVLLTHL HADHAGGLAG
VVDRASPGAV HYATRDAPGQ GRGGRGGEAE GVDPPADAAR LRTGATGTAG PVRWHVLLAD
ARAPEENDAS AQVLVTVESG AGPVTTLVTG DMEEDASAAW VAGRRSDAAA PPRVDVLKVA
HHGARNGGTA VPRAAGARLH VVSVGADNPY GHPHRATVDA LGRLGPVART DLHGTLALTA
ADGPDPEGAP ELAAHTVRPP SSVRTGP
//
