ID C5CD17_MICLC Unreviewed; 764 AA.
AC C5CD17;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Membrane transport protein mmpL8 {ECO:0000313|EMBL:SQG47796.1};
DE SubName: Full=Predicted RND superfamily drug exporter {ECO:0000313|EMBL:ACS31369.1};
GN Name=mmpL8_2 {ECO:0000313|EMBL:SQG47796.1};
GN OrderedLocusNames=Mlut_18860 {ECO:0000313|EMBL:ACS31369.1};
GN ORFNames=NCTC2665_00561 {ECO:0000313|EMBL:SQG47796.1};
OS Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 /
OS NCIMB 9278 / NCTC 2665 / VKM Ac-2230) (Micrococcus lysodeikticus).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Micrococcus.
OX NCBI_TaxID=465515 {ECO:0000313|EMBL:ACS31369.1, ECO:0000313|Proteomes:UP000000738};
RN [1] {ECO:0000313|EMBL:ACS31369.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NCTC 2665 {ECO:0000313|EMBL:ACS31369.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Lowry S., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Young M., Greenblatt C.;
RT "Complete sequence of Micrococcus luteus NCTC 2665.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 /
RC NCTC 2665 / VKM Ac-2230 {ECO:0000313|Proteomes:UP000000738};
RX PubMed=19948807; DOI=10.1128/JB.01254-09;
RA Young M., Artsatbanov V., Beller H.R., Chandra G., Chater K.F., Dover L.G.,
RA Goh E.B., Kahan T., Kaprelyants A.S., Kyrpides N., Lapidus A., Lowry S.R.,
RA Lykidis A., Mahillon J., Markowitz V., Mavromatis K., Mukamolova G.V.,
RA Oren A., Rokem J.S., Smith M.C., Young D.I., Greenblatt C.L.;
RT "Genome sequence of the Fleming strain of Micrococcus luteus, a simple
RT free-living actinobacterium.";
RL J. Bacteriol. 192:841-860(2010).
RN [3] {ECO:0000313|EMBL:SQG47796.1, ECO:0000313|Proteomes:UP000248985}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC2665 {ECO:0000313|EMBL:SQG47796.1,
RC ECO:0000313|Proteomes:UP000248985};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP001628; ACS31369.1; -; Genomic_DNA.
DR EMBL; LS483396; SQG47796.1; -; Genomic_DNA.
DR RefSeq; WP_010080225.1; NZ_LS483396.1.
DR AlphaFoldDB; C5CD17; -.
DR STRING; 465515.Mlut_18860; -.
DR EnsemblBacteria; ACS31369; ACS31369; Mlut_18860.
DR KEGG; mlu:Mlut_18860; -.
DR PATRIC; fig|465515.4.peg.1823; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_4_1_11; -.
DR Proteomes; UP000000738; Chromosome.
DR Proteomes; UP000248985; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000738};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..716
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 722..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 636..751
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 371..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 77751 MW; 3552484535059E0D CRC64;
MPTPPDLSAF RTPAATGRPS RGLRLGLAAA LAVVWLAVLG LGGPVFGAIG DVSSNDQATF
LPASAESTRA GEEAAAFQDG EAVPAVVVGP ASTVDPATAF PALADLAGRL GEVPGVTDVA
GPIPSDDGAA VQFLAFVDSS AGAERPVADV VADLRGVVAD PAAADPALAG TVAADTEWHV
GGPAGLVAEL GGAFAGIDGL LLLVALVVVF VILVAVYRSV LLPVLVLLTA VAALCGAIVA
VYGMALAGWI QLNGQAQGIL SILVIGAATD YCLLLVARHR EELLVRADVG EALRAAVRGS
FGAITASAST VALALLILMA SDLNSTRSLG PVAATGVAFA WLAALTLLPA LLRLTGRAAF
WPTIPSPERA RRRAERRAAR GRAFTPPRDG AGRPIAGLEE DHGVWTRVGA VVARRPRLVW
VATTVVLLAL CGGLLQLRAD GVAQEDVLLG DSDARQAQAL LTEHFDAGAG APAQILAPAG
DAEAVLAAVT EDPGVAEAAV TTDTPEAAAG LPPGALDAEG GTGAASAPEP QPRVVDGRVL
ISATLADPGE SLAAQQTVAR LRDRLADLPA TGEILVGGPA AQALDTNVTT QRDLRVVIPL
ILAMLLVILA VLLRSLLAPV LLVAATVVSF GAALGVSALV FRHVFGFEDA DPTVPLYGFV
FLVALGIDYT IFLMTRAREE TPRHGTRAGV LRALTVTGGV ITSAGVVLAA TFAALAVIPL
MFMVQLAFIV AFGVLLDTLI VRSLLIPALV RDIGPKVWWP AKVD
//