ID C5CFB0_KOSOT Unreviewed; 776 AA.
AC C5CFB0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=CRISPR-associated helicase Cas3 {ECO:0000313|EMBL:ACR79387.1};
GN OrderedLocusNames=Kole_0671 {ECO:0000313|EMBL:ACR79387.1};
OS Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1).
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae;
OC Kosmotoga.
OX NCBI_TaxID=521045 {ECO:0000313|EMBL:ACR79387.1, ECO:0000313|Proteomes:UP000002382};
RN [1] {ECO:0000313|EMBL:ACR79387.1, ECO:0000313|Proteomes:UP000002382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1733 / DSM 21960 / TBF 19.5.1
RC {ECO:0000313|Proteomes:UP000002382};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Noll K.;
RT "Complete sequence of Thermotogales bacterium TBF 19.5.1.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACR79387.1, ECO:0000313|Proteomes:UP000002382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1733 / DSM 21960 / TBF 19.5.1
RC {ECO:0000313|Proteomes:UP000002382};
RX PubMed=21914881; DOI=10.1128/JB.05828-11;
RA Swithers K.S., Dipippo J.L., Bruce D.C., Detter C., Tapia R., Han S.,
RA Goodwin L.A., Han J., Woyke T., Pitluck S., Pennacchio L., Nolan M.,
RA Mikhailova N., Land M.L., Nesbo C.L., Gogarten J.P., Noll K.M.;
RT "Genome Sequence of Kosmotoga olearia Strain TBF 19.5.1, a Thermophilic
RT Bacterium with a Wide Growth Temperature Range, Isolated from the Troll B
RT Oil Platform in the North Sea.";
RL J. Bacteriol. 193:5566-5567(2011).
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CP001634; ACR79387.1; -; Genomic_DNA.
DR RefSeq; WP_015868053.1; NC_012785.1.
DR AlphaFoldDB; C5CFB0; -.
DR STRING; 521045.Kole_0671; -.
DR KEGG; kol:Kole_0671; -.
DR eggNOG; COG1203; Bacteria.
DR HOGENOM; CLU_010123_1_1_0; -.
DR OrthoDB; 9810236at2; -.
DR Proteomes; UP000002382; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd17930; DEXHc_cas3; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002382}.
FT DOMAIN 11..212
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 477..627
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 776 AA; 90157 MW; 0A63231EC2B07974 CRC64;
MSEVYSHPPM GNEPGRLLID HLKGVYYLMM SEIETAKKYM DFERFLGVEY STLKLLVEAI
AYLHDLGKAT PEFQKKIRKL KYDKEKSLHA VLGAFAVGKY LKANLPEEKH YLIPLIVTLV
RRHHGKAEYP EFGCDLNDEV DLLEWQVANL DSKFLNELAY KIQIPKLDPL ELEDNVDEWQ
DEFQDHFYEV NDIQSFILYM YLSSLLDWAD KTDAAFRDRP LPKRDPIPKD LVEEYRKVLG
FDNPGRDPMN QLRNKFYHEA TNDTDFSIGI LKGRTGIGKT LTLFSLGLKL REKLTNSDYV
PRIIYCLPFL SIIDQTYEVA VELFEKTGRS FPTENQVLQQ HHLSDIEYST KEGEGYEKYL
ADLLINSWNS EIIITTFVSF FHSIFTNKRN MKFFRIPGSI VLLDEIQAIP PKYWELTGKI
LKLLADYGGT KFVFSTATMP KCFGISGKHL YTGEIPLDRF DLHYIGEVTF EKFKEIFLRE
VVEKARDESK GLMVVLNTIG CAKAVLEEIS EFVDKKYLYY LSSEVPPIVR KNRIEKLKNL
KGFRVLVTTQ LVEAGVDLDF DYCIRDIGPL DSVVQVAGRV NRSNRKKKGQ VILVDIKEFM
GKRDPSKIYD SVLLFASRKV LSNNDNYSES MLYNLVEIYL AEIETKGFEE ESRMILKNIY
KLEFSKINEF KLIEERPTNP VFIELDENAK NAWKNYQEIL SKDISTQDKF ELLAEKKDAI
RKLAPYIVNY RLKWNESENA LPPVVNGFHY VSNDERELQR YYDSVTGFHS AGSDIY
//