ID   C5DBA4_LACTC            Unreviewed;       696 AA.
AC   C5DBA4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=DNA polymerase epsilon subunit B {ECO:0000256|ARBA:ARBA00016011};
DE   AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|ARBA:ARBA00032930};
GN   OrderedLocusNames=KLTH0A00924g {ECO:0000313|EMBL:CAR21061.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21061.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21061.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC       {ECO:0000256|ARBA:ARBA00009560}.
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DR   EMBL; CU928165; CAR21061.1; -; Genomic_DNA.
DR   RefSeq; XP_002551503.1; XM_002551457.1.
DR   AlphaFoldDB; C5DBA4; -.
DR   STRING; 559295.C5DBA4; -.
DR   GeneID; 8290294; -.
DR   KEGG; lth:KLTH0A00924g; -.
DR   eggNOG; KOG3818; Eukaryota.
DR   HOGENOM; CLU_010628_1_0_1; -.
DR   InParanoid; C5DBA4; -.
DR   OMA; PEDGAWF; -.
DR   OrthoDB; 166885at2759; -.
DR   Proteomes; UP000002036; Chromosome A.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR   InterPro; IPR016266; POLE2.
DR   PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR   PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR   Pfam; PF04042; DNA_pol_E_B; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   DOMAIN          402..656
FT                   /note="DNA polymerase alpha/delta/epsilon subunit B"
FT                   /evidence="ECO:0000259|Pfam:PF04042"
SQ   SEQUENCE   696 AA;  77897 MW;  C8521E9EFD7A5F5D CRC64;
     MDPVVALPVK IQPGLLRPLA YRVLSKKYGL NIKSDGLAAL ADYIGNRFGM NWRKDSGTFK
     FLEQFAAIWD QQERGLFIDR VGVEEVIKEV KERSKASQIP KKVAGEESQS SVRPKTLDNF
     LANRQPSAAE QNILPSSLVA PDVDQDVTDV TEEAQRMEVD EPALPTDSGD LDWQDHFKII
     DAFAQQNFIY DHTTRQYRLK GQRARKVIPQ AESNVAMFAN RYHVVKDRVM RNDLFQGHGD
     TFNPLSSIAG PMSSGPGSFS SQNMTITQIK NLLGRDGRSF LLLGLLRPNY KGGWSLEDPS
     GSVEVDLSQA IPTVGTFYVS GCILLAEGIY FSAGHKFHVA SLAHPPGERR EATMDAIGNL
     DLLGVHQQSS PNYISRIDKD LKIRMHLLER ELTDHRFAFL GGDLFLDQPQ ILEALRKVFA
     KLEGDPPTMM VLQGSFSSAP LFPVMSSKNI SATSAYKNNF DALALLLLNF ERLINETTFV
     FIPGNNDPWS STVSLGTAGV WPQKPIPGIF AQRINRVCKK IHWGSNPTRV AYLSQELILV
     RDDINGRFKR HNIAFPAIMD DEEYGGEVAD SALAQDALMP ELNDNYEGID QLVKSQDQLA
     ASVQESRRLV KTILDQGHIS PFVSSTRPVI WNLDHTLHLT PIPSLMVICD TTASQFEVTY
     NGCKSVNVGS FLYKRRARYV EYRPSSRKVV REEVYF
//