ID C5DBJ8_LACTC Unreviewed; 761 AA.
AC C5DBJ8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN OrderedLocusNames=KLTH0A03212g {ECO:0000313|EMBL:CAR21155.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21155.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR21155.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR EMBL; CU928165; CAR21155.1; -; Genomic_DNA.
DR RefSeq; XP_002551597.1; XM_002551551.1.
DR AlphaFoldDB; C5DBJ8; -.
DR STRING; 559295.C5DBJ8; -.
DR GeneID; 8290397; -.
DR KEGG; lth:KLTH0A03212g; -.
DR eggNOG; KOG2261; Eukaryota.
DR HOGENOM; CLU_010580_0_0_1; -.
DR InParanoid; C5DBJ8; -.
DR OMA; MLGTKSY; -.
DR OrthoDB; 1343374at2759; -.
DR Proteomes; UP000002036; Chromosome A.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 15..157
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 709..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 414..441
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 761 AA; 88007 MW; 166FD7E00DBAF732 CRC64;
MAAPSSQEAA NTRFRHRKIS VKQRLQVYKA SDLRKLDKDE LQQRELVEIE TGVEKNEEKE
EHLHKILQKN QLTRKELYIP TPDASQTWGE YENFYRGKFE EPVSYIRFSA TVEDCCGSCY
NMDERDERFL ESKVNNKLKD GEKLSETEFE LMCSSLEAAI HERQPFLSID PENILSLEEI
KPTILKRDLG DAGIKDKLAE EIGVQPQHFI TQFDSAVQQD SRPITVLFEK FGKQVYNHWK
GRKIEAHGGK ICPQLKSERP GDRDDNDPYV CFRRREVRQA RKTRRVDYQN SHKLRLLHQQ
LLFTKKLALL VAKREKVSLD MLENDLRVFE LRRDIKPIKR SAVIRGDDDL LLDQKKRRLV
SNVVTSTALE SNPKKLRTKS KKANADAANS KVAVAAKPQS RSSQAQSQQS AQQLHSQQQA
LLQQQQAQQQ AQQQKQQANA IAAHVYVKLP SSKIPDILLE DVDDILLKKE RSARNYVEER
MRKRRLEDGE RFFNLTDDPY NPVFDISVPA GVSPTNAPFS SIASSKFEIE KSYYVPGLDN
YLEGKADDVV VLNRDGDRID NPKYRKIERY RPFQQNSGVH TRELPFRLRR RVGRLGLEYI
DRRRPSEAFE PLKSFINLAE VEKQERENDV IDVYDSKLDA LSRLHDRWKH DSDYNDHGAK
FSHEPARLNQ ISNDTQVIRF GTMLGTKSYE QLRDATFKYR QEIYNQRRIQ KNSISQKHPR
VNGVTPASAS TPSMSSTPAR TSSSSSIKRN SNTKQHVASI N
//
