ID C5DD87_LACTC Unreviewed; 1954 AA.
AC C5DD87;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=KLTH0B09196p {ECO:0000313|EMBL:CAR21748.1};
GN OrderedLocusNames=KLTH0B09196g {ECO:0000313|EMBL:CAR21748.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21748.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR21748.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
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DR EMBL; CU928166; CAR21748.1; -; Genomic_DNA.
DR RefSeq; XP_002552186.1; XM_002552140.1.
DR STRING; 559295.C5DD87; -.
DR GeneID; 8291029; -.
DR KEGG; lth:KLTH0B09196g; -.
DR eggNOG; KOG0952; Eukaryota.
DR HOGENOM; CLU_000335_2_0_1; -.
DR InParanoid; C5DD87; -.
DR OMA; MCSATEF; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000002036; Chromosome B.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18022; DEXHc_ASCC3_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT DOMAIN 293..481
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 517..727
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1145..1320
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1351..1546
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1954 AA; 221975 MW; 73CC6AB464998CEF CRC64;
MSTQYSIDSV RSYMDAMSTM VSAAQNFKLG ENIAVAPEID NEIEKSKDES YVQLTTLSQD
RNEWDDIFDS FGELSRANVT NAIESAIAED SSSVTNELKS YMKGINSSEM DEETLLETLL
LLLQSENQDS LQSELLDLLG DENIEFISFL VQNREELISI PPEEIKIALK FENSDGDFLT
HREIRKQYLK NAKDAKNTEL NPLQKQAEYP HVFRKSEVGS SFALSFTGQK FALPVGTTRS
SFATREEIII PAAEAGLRNS MRFKNIVIKD LDVFCTSVFT YETLNAIQSL VYPVAYETNE
NMLICAPTGA GKTDIALLTI LNTVKQFSEV DQKGNIDIEY DSFKVVYVAP LKALAAEIVE
KFSKRLAVFD MKVRELTGDM QLTKAEILET QVIVTTPEKW DVVTRKANGD NDLVSKIKLL
IIDEVHLLHE DRGSVIETLV ARTLRQVERS QSMIRILGLS ATLPNFIDVA DFLGVNRQIG
MFYFDQSFRP KPLEQQLLGC RGKAGSKQAR ENIDNTAYEK MVDMIQRGAQ VMVFVHSRKE
TVRSARNFIS IATSHHEIDL FTEASSIREF YQKEMTKNKD KDVKELFQSG FGVHHAGMSR
SDRNLTERMF KDGAINVLIC TATLAWGVNL PADVVIIKGT QVYDSKKGGF TDLGISDVIQ
IFGRAGRPGF GSSNGTGILC TSSDRLDDYV SLITQQHPIE SKLATKLVDN LNAEISLGSV
TNVEEGIQWL GYTYLYVRMR KNPFSYGINW DEIRDDPQLY ERRKNMIISA ARRLHTLQMI
VFDEVSLHFI PKDLGRISSD FYLLNESVEI FNQLCNPSAT EADVLSMISM SSEFDNMKFR
EEEATELSRL MDNAAQCQIG GEVESAQGKT NILLQSYISR TRIFDSALSS DSNYVAQNSI
RICRALFLVG VNRRWGNFAK VMLDVCKSIE KRLWAFDHPL CQFELPEPVI RQLRDKNPSM
ESLLDLESEE LGDLVHNRKV GHKLYSILSR FPRLEISADI FPITTNVMRI HVALTPAFIW
DMRIHGNAQF FWLFVEESDK SQILHVEKLI LNKRQMSNPH EMDFMIPLSD PLPPQVVVKV
VSDIWIGSES TQVISFQHLI RPHNETLQTK LQRLRPLPTS AMKNPLLEQI YPFRYFNPMQ
TMIFHTLYNT NESVFVGSPT GSGKTVVAEL AMWHAFKEYP GSKIVYIAPM KALVRERVTD
WRKRVTPVTG DKVIELTGDS LPDPRDVKDA TIIITTPEKF DGISRNWQTR KFVQEVSLII
MDEIHLLASD RGPILEMIVS RMNYVASQTK RPVRLLGMST AVSNAYDMGG WLGVKDNGLY
NFSSSVRPVP LKMYIDGFPD NLAFCPLMKT MNKPAFMAIK QHSPDKPVLI FVASRRQTRL
TALDLIHLCG MESNPRRFLN IDDEGELQYY LSQVSDETLK LSLQFGIGLH HAGLVEKDRY
ISHELFQKNK IQVLVATSTL AWGVNLPAHL VIIKGTQFFD AKIEGYRDMD LTDILQMMGR
AGRPAFDTSG TAIVYTKQAK KMFYKHFLNI GFPVESSLHK VLDDHLGAEI ASGSIANKQE
AMDFLSWTFL FRRAHHNPTY YGIMEDTSAA GINKHLSNLI DDTLKNLEES SCVALRGNEI
EALPFLSISS YYYISHKTIR QLLKHIKNTA SFQEVLKWLS LAFEFNELPV RNGEIIMNVE
MSAQSRYSVE STFVGEDELP MWDPHVKAFL LLQAYFSRVD LPIADYHQDT ISVLDQALRI
LQAYADVAGE LGYYSTVLTI IKAMQCVKQG CWYEDDPVSL LPGVGLKRIT DCEFSETGFP
LEKSHSMNLD KIGRLKFKQL EQVARKLNVE KEKIKDFIGE CQKLPVLDNI RVEPQSDPNE
LVITAVHANP RHNRNFEVYC ERFPKTQKEL WFVIGYQGEE LMMVKRFQPR RKNNGVAISG
EFVVAEELHG QTLRFTIIND ALDIKYDFEH TLAR
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