ID   C5DFX3_LACTC            Unreviewed;       522 AA.
AC   C5DFX3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=KLTH0D00682p {ECO:0000313|EMBL:CAR22315.1};
GN   OrderedLocusNames=KLTH0D00682g {ECO:0000313|EMBL:CAR22315.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR22315.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR22315.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; CU928168; CAR22315.1; -; Genomic_DNA.
DR   RefSeq; XP_002552753.1; XM_002552707.1.
DR   AlphaFoldDB; C5DFX3; -.
DR   STRING; 559295.C5DFX3; -.
DR   GeneID; 8294973; -.
DR   KEGG; lth:KLTH0D00682g; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   HOGENOM; CLU_005391_5_1_1; -.
DR   InParanoid; C5DFX3; -.
DR   OMA; HGIGYYP; -.
DR   OrthoDB; 216092at2759; -.
DR   Proteomes; UP000002036; Chromosome D.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR   CDD; cd07091; ALDH_F1-2_Ald2-like; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR11699:SF268; MAGNESIUM-ACTIVATED ALDEHYDE DEHYDROGENASE, CYTOSOLIC-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   DOMAIN          54..513
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        290
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   522 AA;  56627 MW;  09272F1451166DEA CRC64;
     MLSRTGTALR GMPVAATRLG MRFYAQLPLR VPVKMPNGIE YEQPTGLFIN NKFVRAKQGK
     TFEVVSPATE EEITHVYEAR EDDVEDAIAA ADQAFKSGVW SDADPLVRAK ALNKLAELIE
     EDLETIASIE TLDNGKAISS ARGDVQLVAN YLRSCAGWCD KIDGRLINTG STHFSYTIRQ
     PLGVCGQIIP WNFPLLMWAW KVGPALATGN TVVLKTAEST PLSALYVSQF VPKAGIPAGV
     VNIISGFGKI IGEALTTHPK IKKIAFTGST ATGRHIYQNA GANLKKVTLE LGGKSPNIVF
     ADADLKATVQ NIILGIYYNS GEVCCAGSRV YVEESVYDQF LEELKAATEN VKVGDPFDDA
     TFQGAQTSQM QLSKILKYVE IGRDEGATLV TGGERLGNKG FFVKPTIFGD VTEDMRIVKE
     EIFGPVVTIT KFKTVEEVIE KANDSEYGLA AGVHTKDINK AIEVSNRVNS GTVWINTFND
     FHHAVPFGGF NASGIGREMG IEALENYTQV KAVRAKLTLS GK
//