ID C5DG40_LACTC Unreviewed; 1379 AA.
AC C5DG40;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=KLTH0D02200p {ECO:0000313|EMBL:CAR22382.1};
GN OrderedLocusNames=KLTH0D02200g {ECO:0000313|EMBL:CAR22382.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR22382.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR22382.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU928168; CAR22382.1; -; Genomic_DNA.
DR RefSeq; XP_002552820.1; XM_002552774.1.
DR STRING; 559295.C5DG40; -.
DR GeneID; 8295040; -.
DR KEGG; lth:KLTH0D02200g; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_004883_0_0_1; -.
DR InParanoid; C5DG40; -.
DR OMA; PFILMYD; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000002036; Chromosome D.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT DOMAIN 38..168
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1131..1373
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 602..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1379 AA; 156204 MW; D8CE4E59E485315A CRC64;
MVPEDLQDEI EQGGRIFGTD DYYPMPSEEK LSFSKRGSST LIIKTDISAL IVKLTSPMDP
IDYPFLSDFF LSYRKFLAPQ ELLKLLVSRL QWAFNESLSA DSNKQQIGQI ASVRTFVLIR
HWILNYFAQD FLTDDALRSQ FVNSVNSLSW GASDVAPKSI CGIVINIKKS WGFCLRLMWE
GLSFEDQPTS ANEWLEFKIK DVATHLSTKN GKRLSFYALQ SSQNPEFRNR SVLSLYVGKE
NFQLPEHNAR VNTKQGAKIK QRTASMFLFP QDNLSSAVLK VSNDKVGNSD EVSQNAPNSS
GVSEVIKDLQ YPPSPSIDKV IPPTPAKKVE FILRSSYFPS EILSEEEANT SSTSQKLKKE
PHLHSYNKGM MGLLSKWKKN HTLRSANQKI NQESPSAEFE NLIKLVFSIT SLENKQYSSE
ELKSVVSSKF DILSARTIDE VEYFLAVEND LLSKIRKQDH FTTVEGGADE QTQERDAETV
SAMDNLNLYK TVSSIASSVI SLSKTLQFQH AVSPSAAARE RRRVRSTDGL LGNKSVLNFT
DALLTSDVNT RILENDAPRK LVFHGHSTTR ERHTNSELKF RYSNMADAVI RLNHSTPSVM
QTSALTKSTN GTRSRGSPTK GVRISSSITE IDDTFSKHNE STPQAEEVSN AGSHISRPLK
RKESLDNLRE FNFEENFDQK NGSQSKLDHK INHNELQSDA DDDNSSFFTT LDDMSMSRNS
KHMTPASSAA QKSVTSSGRI SIIRSRGPSV SNAVTISTTN LVAKDGAFLK LDEELLNNQE
EIRNLEERTS ALFFDKVEEE GAKNIRSSIA TSVSTQLLFS SKQSSPNKIE KNDLLDNDEF
PQGNKLIRLS SIPSMHSIVS GDSFSSFHTI NSFEQNSRAD ISHKLTVDTP STGAKPEKNA
PNDSLLVPDA EGSSGNKYLF SPDTDSLDFA SPEKNMEDLK NKFISPITSE TTSFNEDDLS
RDNEGEEGEP TEEQQLDNGY QEKPHNEHHR RSITPIVSPY KANDSRLNRF AKLTDESLHG
DPVNVALMKL EGTFSKTDQN KEQSDSDMER LKERRLTGLG ARERNSFLIE RRRQVKSEVP
FTPCTKDFSY ERDQKVTNDQ ITELLQNYKI QDSRLNISNA EQHVPFILMY DSKSIAEQLT
LIEREILNEI DWKDLLDLRV KRKVLPVTSW LQLLLQNEQL SGIDLAIARF NLTVDWIISE
IVLTRDNKLR RNTIQRFIHV AEHCKLFQNY NTLMQIVLAL SSLVVQSYRD AWRLVEPGDL
LSWESLKNVP SLEKNYYNIR MLLNDIEPIK GCIPFIVVYL SDLTLNSEKS NWITPHQVLN
YSKFQTNVQI VKNFIQRAQW SKFYNISVND ELLSKCVYIS CLTHEEIDHL KSQQTKSAT
//
