ID C5DIR6_LACTC Unreviewed; 653 AA.
AC C5DIR6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN OrderedLocusNames=KLTH0E14608g {ECO:0000313|EMBL:CAR23677.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR23677.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR23677.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR EMBL; CU928169; CAR23677.1; -; Genomic_DNA.
DR RefSeq; XP_002554114.1; XM_002554068.1.
DR AlphaFoldDB; C5DIR6; -.
DR STRING; 559295.C5DIR6; -.
DR GeneID; 8292284; -.
DR KEGG; lth:KLTH0E14608g; -.
DR eggNOG; KOG1625; Eukaryota.
DR HOGENOM; CLU_014923_1_0_1; -.
DR InParanoid; C5DIR6; -.
DR OMA; PFLDIEH; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000002036; Chromosome E.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT DOMAIN 18..251
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 356..589
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 78..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 653 AA; 72294 MW; 6FC5E848D2D22664 CRC64;
MTLENELVGK FGKPAGEPAV ASALESLMKI HSLDVEELYI KWEQFAYHQN EQSTALNVDM
INAFKQFLQQ QIEKKASMAG GPGSAASSLK KPKMLRPNVS SPSLFGFGAP KTPTLKKRRV
DQTPTQSNIE GDTISLASPT EKKEASTMPP SVRLAAGESP VTPSLLANNP DPGKVVDVFN
LADIEVSEGL NLDGEKLVKP IPFYDSEKYK FRTMRQNLLD VADVLDEQIE IFTKVFQDHY
KTTASDPTIQ SQSEITAVGR IVPDSPAADG MLNTESLALE TSRLTGIGRR IPLNLERTKE
VSLFPGQIVG VRGKNASGDY FVVEEFLQIP HLNSPVSTEG ELQSFNEDLD GKSMKVVVTN
GPYTASNCLD FGNLEDFVER LNDGVKPHVV IMFGPFLDVT HPLVASGRIP EFPGVKVQPK
TLDEVFTKII SPILRKINSK IQVVLVPSTT DTASNHAAYP QDCFDRKQLQ LPKNFKCFTN
PSTFQLNELF VGCSNVDAFK DIKEVVKGGA TCSKNRFDRI AEHILSQRRF YPLFPGALKR
RKLRLEDGHD VWEHVSGADL EVSYLGLTEF VANLLPDLVI IPSELSYFTR VVQNVLFINP
GMFIRPTGLR GTFAQLSILP PDLADGRLTK VEGDEMVYLH NLWKRCRVDI VTA
//
