ID C5DJ36_LACTC Unreviewed; 658 AA.
AC C5DJ36;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=KLTH0F13178p {ECO:0000313|EMBL:CAR24325.1};
GN OrderedLocusNames=KLTH0F13178g {ECO:0000313|EMBL:CAR24325.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR24325.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR24325.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR EMBL; CU928170; CAR24325.1; -; Genomic_DNA.
DR RefSeq; XP_002554762.1; XM_002554716.1.
DR AlphaFoldDB; C5DJ36; -.
DR STRING; 559295.C5DJ36; -.
DR GeneID; 8292986; -.
DR KEGG; lth:KLTH0F13178g; -.
DR eggNOG; KOG1386; Eukaryota.
DR HOGENOM; CLU_010246_3_3_1; -.
DR InParanoid; C5DJ36; -.
DR OMA; WHDALFD; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000002036; Chromosome F.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IEA:UniProt.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF121; NUCLEOSIDE-DIPHOSPHATASE MIG-23; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 514..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 153
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 188..192
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 658 AA; 74012 MW; AC885BF52994F07C CRC64;
MRQSQGNALN HDQYGVVIDA GSSGSRVYIY KWQDPAYTSK VGDTENLYSV PRISLSKEWT
TKTSPGLSSF KKKPNKAFKD HIKPLLQFAE DIIPKENLKS TPVFIQATAG MRLLSDKKRD
LILGDLCSGI KHSTNFLLED CRSQVQVIDG ETEGIYGWIG LNYLLKNFDN YNASDELHTS
FGFMDMGGGS AQVAYVPNNP REIEKHDDDI SSVILRSLNG ETQTWRVFVG TWLGFGANEA
RSRYLAQIVN SLPENTNDRN DDDFLTRELV DPCMLKGSHT KFKFKDKYFH FSGSGNFEHC
SKSIFPLLRK DTPCIEEPCL FNGVHAPAID FYNDKFIGTS EYWYTANDVF QVGGEYNFHD
FSQKVKEFCE SDWKEVEEHS KNGRYNNIPI KLLLDSCFKA NWILSVLHEG FDMPRVGIEI
TDDQETKDRD TSEGAAASVA FQSTDSIEGY DLSWTLGKMV LYVSGLVEAS RGDASVGISP
SRNDIKIFGK DFIPGSILGQ GLSATESSSL FKQFMKIIVV VVVAIIALML WTVLFPQKAS
RVSRLKSFVK YLKSRLSRWW RSDLPRLSSL SSLEEGLFVR TGLESDDRDG NQVRSRSMVS
LEDARKLSAE QYSMDSPVSN HSGNKFVRTN LRPAFSLADF SKFAKSAPSD RESGHVNI
//
