ID C5DJC1_LACTC Unreviewed; 554 AA.
AC C5DJC1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 08-NOV-2023, entry version 69.
DE RecName: Full=Vacuolar protein sorting-associated protein 17 {ECO:0000256|PIRNR:PIRNR011791};
GN OrderedLocusNames=KLTH0F15202g {ECO:0000313|EMBL:CAR24410.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR24410.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR24410.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SUBUNIT: Component of the retromer complex.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SIMILARITY: Belongs to the VPS17 family.
CC {ECO:0000256|PIRNR:PIRNR011791}.
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DR EMBL; CU928170; CAR24410.1; -; Genomic_DNA.
DR RefSeq; XP_002554847.1; XM_002554801.1.
DR AlphaFoldDB; C5DJC1; -.
DR STRING; 559295.C5DJC1; -.
DR GeneID; 8293076; -.
DR KEGG; lth:KLTH0F15202g; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_028982_1_0_1; -.
DR InParanoid; C5DJC1; -.
DR OMA; FYLGTME; -.
DR OrthoDB; 1708746at2759; -.
DR Proteomes; UP000002036; Chromosome F.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR PANTHER; PTHR47433; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR PANTHER; PTHR47433:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR Pfam; PF00787; PX; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR011791};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW Transport {ECO:0000256|PIRNR:PIRNR011791}.
FT DOMAIN 103..221
FT /note="PX"
FT /evidence="ECO:0000259|SMART:SM00312"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 61956 MW; 802BB24D7ECB964D CRC64;
MSSAVAYDPY DDIDNNPFSE PEANPQRSVS PDLRAPDDTH PSIGAQEATQ GNTDSHAGAQ
PEPEQGMTTA QHGNPPGDFP EASTTAAAAE GADALLPERR SSKFQLVVKV TGLERVGSFT
NKKENPTVKF DVSTNLPTFR KQQHRSLKKT FTEFRNLRKF LYGLISGTFV PALPSPSTNY
GISNSEDYCK TVSNMQEWFD RIAVDPFILR SEELAFFIES DFDTYTPVGK TKLPLSGLKR
KTLKQLAPPF DECLELAEFR PLVKSVHHLS QDIQTKLLKL CKLRKSLSHD ENSIGQGFKE
LCMDQSQSHS KFYNKFGKTL SAVGDIDSVM ATLDIATLYD GLEWLVQETY SVKEALTNRH
FLMRDLLQAQ QTSSSRQEQA RKLRARRDVS PLKVDEAIRA LKAATTAEHT LTLKLRRVTA
NMLLEKQRWL EWCDHQLQTS IKEYTLRKIE YERKKLSLLE RIRADVRAAD EAGGLSRLGR
GARLSASGVS PSQTAQGDSW TSDPRSRAFE PSVLRTEFDA SLESDTRDVH DTHPEDQHAL
DARSAASLLG TSSF
//
