ID C5DKD3_LACTC Unreviewed; 379 AA.
AC C5DKD3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=Ribosomal RNA-processing protein 43 {ECO:0000256|ARBA:ARBA00030617};
GN OrderedLocusNames=KLTH0F03718g {ECO:0000313|EMBL:CAR23934.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR23934.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR23934.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, nucleolus {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
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DR EMBL; CU928170; CAR23934.1; -; Genomic_DNA.
DR RefSeq; XP_002554371.1; XM_002554325.1.
DR AlphaFoldDB; C5DKD3; -.
DR STRING; 559295.C5DKD3; -.
DR GeneID; 8292565; -.
DR KEGG; lth:KLTH0F03718g; -.
DR eggNOG; KOG1613; Eukaryota.
DR HOGENOM; CLU_065411_0_0_1; -.
DR InParanoid; C5DKD3; -.
DR OMA; FDLCYLS; -.
DR OrthoDB; 2045481at2759; -.
DR Proteomes; UP000002036; Chromosome F.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:UniProt.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:UniProt.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProt.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IEA:UniProt.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:UniProt.
DR CDD; cd11358; RNase_PH; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11097:SF9; EXOSOME COMPLEX COMPONENT RRP43; 1.
DR PANTHER; PTHR11097; EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT DOMAIN 43..232
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
SQ SEQUENCE 379 AA; 41652 MW; 34361DA1F6092209 CRC64;
MTESLELRPI TFHPDVLARI APELSMQRHL SLGLRPSLRS FEEFRNVEIS DGGLSFASNA
DIDRKGNNIL GSNVLKCGKT MVVTSITGGI VEENISGSRV DDESTESSNR ADRLSRFAQV
HPVVEVERGR VGAPTDEEMT LSQRLRDCVL HSGLIPKKAL DVAVGIRSTD SEGISSILYP
DEEENTISSG LKSRRKWSYV LYAKIQVFSR DGPLFEICWN SLIYALKTTQ LPRAFVDERT
ADLKIPVSMR GRSATFRETF DIICDASKFQ PLVLNEENVA FASNFAIIDV DPETELPKDE
DEMQVDQGGS VLLADIQGEA EEASVFSTIS IISSDAGRLK HFKVIGGGLN ASMEHLKKSL
NLAKLRASDL SAKSSSGDR
//
