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Database: UniProt
Entry: C5EQU1_9FIRM
LinkDB: C5EQU1_9FIRM
Original site: C5EQU1_9FIRM 
ID   C5EQU1_9FIRM            Unreviewed;       456 AA.
AC   C5EQU1;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   20-JUN-2018, entry version 57.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EEQ60385.1};
GN   ORFNames=CBFG_04097 {ECO:0000313|EMBL:EEQ60385.1};
OS   Clostridiales bacterium 1_7_47FAA.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales.
OX   NCBI_TaxID=457421 {ECO:0000313|EMBL:EEQ60385.1, ECO:0000313|Proteomes:UP000004695};
RN   [1] {ECO:0000313|EMBL:EEQ60385.1, ECO:0000313|Proteomes:UP000004695}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1_7_47_FAA {ECO:0000313|EMBL:EEQ60385.1,
RC   ECO:0000313|Proteomes:UP000004695};
RG   The Broad Institute Genome Sequencing Platform;
RA   Allen-Vercoe E., Strauss J., Ambrose C., Ward D., Gujja S., Young S.,
RA   Jaffe D., Gnerre S., Berlin A., Heiman D., Hepburn T., Shea T.,
RA   Sykes S., Alvarado L., Kodira C., Borodovsky M., Lander E.,
RA   Galagan J., Nusbaum C., Birren B.;
RT   "Annotation of Clostridiales bacterium 1_7_47_FAA.";
RL   Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00747961}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; DS990262; EEQ60385.1; -; Genomic_DNA.
DR   RefSeq; WP_008723100.1; NZ_DS990262.1.
DR   ProteinModelPortal; C5EQU1; -.
DR   STRING; 457421.CBFG_04097; -.
DR   EnsemblBacteria; EEQ60385; EEQ60385; CBFG_04097.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004695; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004695};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00747973};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004695}.
FT   DOMAIN      148    280       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      363    432       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     156    163       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   456 AA;  52380 MW;  571207F31AAFCD8B CRC64;
     MIDKIKENWE QILLTLKEEH EISNISYSTW LEPLKPYSFK DNTVIIIVPE QTFLQYVNKK
     YGFLLKVTIS EFLEKECEVD FKVKEQIIEK EEPSGPQLIQ KNTVTISPDV IQSANLNSKY
     TFDTFVVGSN NNLAHAAALA VAESPGEIYN PLFIYGGVGL GKTHLMHAIA HFILKNNPSS
     KILYVTSETF TNELIDAIRN KNNITTTEFR EKYRNNDVLL IDDIQFIIGK ESTQEEFFHT
     FNTLYESKKQ IIISSDKPPK EIETLEERLR SRFEWGLTVD IQSPDYETRM AILRKKEEME
     GYNIDNEVIK YIATNIKSNI RELEGALTKI VALSRLNKCD ITLELAEEAL KDIISPNAQR
     EVTPDLIIQI VSDHYGLTPL DISSQKRNKE IVYPRQIVMY LCRNMTDTPL QTIGRYLGGR
     DHTTIIHGSE KIAGDIKKDD TLKNTIEILK KKINPQ
//
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