ID C5FCP3_ARTOC Unreviewed; 3918 AA.
AC C5FCP3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Non-reducing polyketide synthase nscA {ECO:0000256|ARBA:ARBA00018393};
DE AltName: Full=Conidial yellow pigment biosynthesis polyketide synthase nscA {ECO:0000256|ARBA:ARBA00031359};
DE AltName: Full=Neosartoricin B biosynthesis protein A {ECO:0000256|ARBA:ARBA00033379};
GN ORFNames=MCYG_00465 {ECO:0000313|EMBL:EEQ27577.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ27577.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC family. {ECO:0000256|ARBA:ARBA00029443}.
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DR EMBL; DS995701; EEQ27577.1; -; Genomic_DNA.
DR RefSeq; XP_002850361.1; XM_002850315.1.
DR STRING; 554155.C5FCP3; -.
DR GeneID; 9225582; -.
DR VEuPathDB; FungiDB:MCYG_00465; -.
DR eggNOG; KOG1178; Eukaryota.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_37_5_1; -.
DR OMA; GGWLINM; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..438
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2354..2429
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3508..3584
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 2434..2489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2437..2451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2464..2489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3918 AA; 432142 MW; A94AAB78E1B8A120 CRC64;
MPQRKEPIAI IGSACNFPGN STTPSKLWEL LKEPRDLSKP IPDNRFNADV WHHKDNSHHG
TSNVTKSYFL EADPAVFDAN FFNIPPNECE AIDPQQRMLL ETVYESLCAA GVTMEGLRGS
STACYVGLMC DDWAGMLAKD WDCLPQYAAT GISRAIMANR ISYFFDWHGP SMTIDTACSS
SLVAVHEAVQ VLRSGDCNVA VACGANLILT PGMYIAESKL KMLSPDGKSR MWDQGANGYA
RGEGLAAVVL KTLSQAIKDG DNIECVIRET AFNQDGRTTG ITMPSNLAQT ALIRETYKKA
GLDPLNPNDQ PQYFHAHGTG TPAGDPQEAE AISRAFFNDG QVAEKKLWVG SIKTIIGHTE
GTAGLASLIG TSLALQNKTI PPNLHLNQIA EKVKPFYTNL EVPTTSHEWP SPPAGQPMRA
SVNSFGFGGA NAHAILESYD PIENQASCKE TERSLFTPLT FSANSEKSLR GMLETFSQYL
SAENAPDISD VAWTLQNHRS ALVYKIAISG RMTTDLVAGI DAARNQKDSI GVRSSGPEKL
TVLGVFTGQG AQWPTMGREL IKTSGHVRNI VAGLDRSLQE LPERDRPNWS IQGELEADNK
SSRLSEAALS QPLCTAVQIV LVDLLKAAGT NLEFNAVIGH SSGEIAAAYA SGFISARDAI
RVAYYRGLYA KFARSPSGKK GAMMAVGTTL EDAEEFCQLD EFEGRITVAA SNAATSVTLS
GDGDAIDKAQ VVFKDESKFV RKLRVDTAYH SFHMNSCSEM YLKAMHTCGI EYKEGYSSVS
WYSSVIPDKK MASSDLNGQY WADNMNNTVL FSQAGITAVK ESGPFDLVIE IGPHPALKGP
CLENLEQATG VGGTPYTGLL SRGVDDVKAF SAALGYIWEC FGSAAVDFGG YDKLMSANSQ
RRNLSAELPE YSWDHTRSYW LDSRVATSYT TREAPHPMLG VNAVEGSTGT QIQWRNILFP
KEISWIPGHR LQGQNVFPAS GYVCMAIEAI MTLSNNREVQ LIELEDVDIA RAISFLDDTA
GIEIIFTLNV LSSEPELISA NFQISSCPKG DNTLTLNGKG KISIRFGESI VDALSVSQVP
QFNMASVDID RFYKYLSDMG YNYSPPFKAI SSILRRKDAA VGEITDSRGG SWEDSFLMHP
GFVDTSFQAV FAAFSSPGDD RLWSIHVPTK INRLSINPSL AVFPPGEEIV WPWQAVVTSE
THDTPTADIE VFAPNKNGVL MEIEGIVLVP LAKASEENDV KLFSNLIYDL AQPDGVVAAP
NRLSKPDAHI AKVSERFSFY WINKLLNSIT TKEEEETLSH FKYMLRWYRA DISILRAVGQ
NIAHVIRTRG NIHEYTLKDN ILDRFYEEAI GLDITNQWEA NLAAQVAYRY PRMNIIEIGA
GTGGSTRMIL PTLDKAFSTY TFTDISSGFF EAAEKRFSQY SDRMIFKTLD MEKDLSEQGF
TEGHYDMVLA SNVLHVGPDI DLTLSNVRKL VKPGGWLINM EVATYFPSLR EGFSMSGFPG
WWCGAETGRP WGPTIPVEEW DKVYKRTGWS GIDALTPNID SIDHLVVMAT QAVDPQIYTL
RDPLALEHAH PQRENLVIIG GKTEEVANIV TECSSILRSH FSSIRNVTCI DNFSNSDTKA
VATVLNLAEL DVPIMKELMD DQPQKLEGVK EVFSTPREIL WVTKGNRSES PYSRMLVGMA
RTLRREYSGI NFQALDVDVL DSNSAKLFAE TLLRHLNLQA ANNQLVPDSI LWSDESEYHL
EKNKIYIPRL ISADKINDRY NSYKRRITHE ASARDSNIEL ISKSNSYNLC EPSPLKPTTR
SESDSEITVS QSLLQSVEVP LVGHFFLCYG TDDCGEHVIA LSDRSNSVVH VPRSWTIPYG
GTPNPEQVIL SVAANLVAHL IIADISANST ILVHDPDQIV AAAISKQAAT KKIQVFFTTT
QTSKKGPQWT YIHPKTPRRL LKKQLPKRIS TFINFSSISD KQTMVNLLDS LPLCCKQSDR
SMFFGNSVAK RPGSNAELVS KILTTGFDIA KTTNFSVPYN RSTLPLDRVP GYSDRTKDLM
VIDWVTDNKI SLTVEPIDPY ADLFSAEKTY LMIGLSGEMG QSLAEWMVNR GARYVVLTSR
RPKVNTEWIE SMEDEYGATI KSMPLDITDA DALHSCYNKI CRTMPPIGGV AHGAMVLVDS
LFQKMSYEDL MAALRPKVLG AINLDNLFSE NTLDFFILFS SITALIGNAG QSNYIGANSF
MESLGLQRRR KGLSASVIAI SSLIGLGYFE RAENLDIDQF SRSGYRNVSE QDIHTLFAEA
IVRGRPGTTE SHEVVSGVVP TYADGDIRAS YLKDMKFSHL ILERTSAKQD GSSSTQIPVR
IQLLTATTED EVREVMQSGL TRRIKKMLRI PEEDVFNATD SLVEQGVDSL VAVEIRTWFI
REIDIDMPVL KVLGGSSISD LLNDAIQKIS PELTPCLGSK GTKSNLNGHP TPPKEVPNPS
FKPAAIDSSP SVTQDTQSQS KSPNTSLVHS TPLTITAITE TPAKPLGDEP RLAVENSNIQ
QGLGRREKSE VTEKMSFGQS RFWFLNQALN DKTTFNMAIL VRLSGRIRVK DMERALELVV
LRHDALRTRY FSTGEYMESP MQGVISTSAV KLVVKHCKDE SAAYRELDEL RSHVWDIGDW
ETMKVSLLSS SDTMHYLVIG CHHIGMDGFS FNVFYSDLEK AYEGQKLPII PKSSQYGAFA
RKQREDWENG NMNADLAYYR EIIPRNLNPI PLFPFAKTST RLPLDTYDTY SADVRIEPAL
TKKIKAASRF LSSTTFHFYL AVLQTLIFRQ LDDCDEFFIG VADANRTDDK FINTLGFFLN
LLPVRFERHA AKKFGEAVKQ VRDKVYTGLA HSKLPFDVLL DELKIPRSAT ATPIFQVFVD
YRQGVQERQK YMGLDAVGEK WHLARTGYDM TLDIVENAAG DTRLELRLQK RLYTAQHTKL
LLNGYVNLLT AFANNPTADW SVPDVWDSQT ISNALEVGRG RSLQYEWAPT VMHHIDNVVS
QYGTNICLKD GTGKTMTYSQ MADRVNSICA ALIATKVIGG DKVAVFQQPT ADWVCSLLAI
FRAGAVYVPL DLRSPLPRLA AIVDQARPCV IIAHSQTLRD VKHLEVPNAV VVNVSSLATS
GQAMPNLAKP DELAVVLFTS GSTGIPKGIH INHSNIIKQL EGCSKQFEFK GTASYVLHQT
AYSFDKSLEQ IFTALVHGGA LYVVPAEQRG DPISITNIMA SEGITHTATT PSEYLMWFRY
ARDNLLKCKT WKCALLGGEV ASDAVIEEFR KLGMPIRLLD SYGPAEITMS CAKVELPYRS
MITGHPAPVG FMLPNYSVSI VDSQMNPLPL GFVGEIVIGG VGVASGYLNN DELTKQKFIQ
NSFGGDGMVY RTGDKGRLTE EGALFFEGRI DGDTQIKLRG VRIELEDIES TILQASAGAL
THAVVTLRGK QDSTFLVAHV VFSATYAEPR DDLLTRLPIL LPLPQYMIPT IFIALDNLPF
TTHFKVDRKA VLALPVPEVG NASTEQIIGL TETEAQLAIL WNHIIPATRV LIPGSDFFHA
GGNSLMLVKL QAMIRQSFSV SLRLFDIMNA GTLRSMACLI EDALGAKELD WDAETALPTL
PSRNPDISPP KHKDIVVMMT GATGVLGKNV LAHLVADDRI SKIYAVAVRP QNGISALTRI
LDPKKKINIK HGDLDKARLG LSEKEAIILA SEADVILHLG ANRSFWDSYY HLRAINVFSV
KEIVKIAHPR NVPIHFVSSG GVSAYSFNSP PTNGHDGYVA SKWAAEKVLA NAANEVGLKA
VLHRPTKAPG GTSVAPTEIL DELLSLAKQL QKKPALDGLS GSLGIVPLEH IAEDIVRTIF
GTEMIGLGQP EVITHSSTLN VNIKEFADRI LQDQDVSALE EMPALQWMGL AKKGGWSQFM
VGHEIHMHNS NDRIVSTR
//
