ID C5FDV6_ARTOC Unreviewed; 685 AA.
AC C5FDV6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Beta-lactamase domain-containing protein {ECO:0000313|EMBL:EEQ27990.1};
GN ORFNames=MCYG_00878 {ECO:0000313|EMBL:EEQ27990.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ27990.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Type III
CC sulfatase family. {ECO:0000256|ARBA:ARBA00033751}.
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DR EMBL; DS995701; EEQ27990.1; -; Genomic_DNA.
DR RefSeq; XP_002850774.1; XM_002850728.1.
DR AlphaFoldDB; C5FDV6; -.
DR GeneID; 9226705; -.
DR VEuPathDB; FungiDB:MCYG_00878; -.
DR eggNOG; ENOG502RJJX; Eukaryota.
DR HOGENOM; CLU_014655_1_1_1; -.
DR OMA; AQHEHDH; -.
DR OrthoDB; 5394742at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0018741; F:linear primary-alkylsulfatase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0018909; P:dodecyl sulfate metabolic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd07710; arylsulfatase_Sdsa1-like_MBL-fold; 1.
DR Gene3D; 1.25.40.880; Alkyl sulfatase, dimerisation domain; 1.
DR Gene3D; 3.60.15.30; Metallo-beta-lactamase domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR038536; Alkyl/aryl-sulf_dimr_sf.
DR InterPro; IPR029229; Alkyl_sulf_C.
DR InterPro; IPR029228; Alkyl_sulf_dimr.
DR InterPro; IPR044097; Bds1/SdsA1_MBL-fold.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR PANTHER; PTHR43223; ALKYL/ARYL-SULFATASE; 1.
DR PANTHER; PTHR43223:SF1; ALKYL_ARYL-SULFATASE BDS1; 1.
DR Pfam; PF14864; Alkyl_sulf_C; 1.
DR Pfam; PF14863; Alkyl_sulf_dimr; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 119..350
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 685 AA; 75353 MW; D013FC3784E66D00 CRC64;
MFLLSKLGYI AEQNTQTGPL LHINRSTFSP SPLATPSQVK MNDDFEFAQR GLLSTPKRSL
VISDFGRDVV WNFNAYAFLE DEAPNTVNKL LWRQGQLCSA TPGLYQVIDG IYQIRGYDLA
NMSIIQIPNS NGIIIVDCLT SVETARSAIE LYLDYYKDKH NQDAEIKALF YTHCHIDHFG
GAQAIVDLAK AGGNSNLPIY GPDGFLEHAV SENIYAGAAM TRRSIYMYGE VLPRSPEGQI
GCGLGQAVST GASSLVAPSH VITEDGPLKV AVEGLKITCQ LTPGTEAPAE VNFYFPDYLA
LCMAENATHT LHNLQTLRGA PVRDGRLWSR YMDESIALFG DKTDVVFSSH HWPTWKEDKD
LVVKFLSEQR DYYAYLNNET LRQLNDGKTP LEIAEDIQMP PSLSSRTNLR GYYGSISHNA
KAVYDKYMGW FDGNPAYLWP LPPTAESIEF VKCMGGNEAV LKLAQGYRTD KNYRFAATLL
DKLIFATQSN PAEKDGETAK QAKQELAAVY TALGYGAENG PWRNIYLTGA YELKNGATAA
VNSVSSQSMM NVSLDQLFDT IAILMDGPKA FKQPKVYLEK EISIDFMVED IAQLKKMGAG
WHMRLSNAAL TGHAVGYTAP PNPRSAGVAL TVWLKHEQLV SLIVAAATGK NPNLDNLTIS
GDVDAWAKVM AIITLPSTAF NIVTP
//
