ID C5FG50_ARTOC Unreviewed; 601 AA.
AC C5FG50;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=MAP kinase activator {ECO:0000313|EMBL:EEQ29735.1};
GN ORFNames=MCYG_02554 {ECO:0000313|EMBL:EEQ29735.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ29735.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS995702; EEQ29735.1; -; Genomic_DNA.
DR RefSeq; XP_002849620.1; XM_002849574.1.
DR AlphaFoldDB; C5FG50; -.
DR STRING; 554155.C5FG50; -.
DR GeneID; 9222590; -.
DR VEuPathDB; FungiDB:MCYG_02554; -.
DR eggNOG; KOG4773; Eukaryota.
DR HOGENOM; CLU_014957_1_0_1; -.
DR OMA; FICAHHN; -.
DR OrthoDB; 1368965at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05992; PB1; 1.
DR CDD; cd06890; PX_Bem1p; 1.
DR CDD; cd11879; SH3_Bem1p_2; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035550; Bem1/Scd2_PX.
DR InterPro; IPR035549; Bem1/Scd2_SH3_2.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF2; BUD EMERGENCE PROTEIN 1; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EEQ29735.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:EEQ29735.1}.
FT DOMAIN 32..97
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 159..221
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 304..424
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 525..601
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 102..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 68050 MW; 49D448B075BC5233 CRC64;
MKVSRLPRSL KGEKEKSQHV SITPKSALAI LPPKKVIKAL YDYQPSPDNR EELAFSKGDF
FHVISREDDL SWYEACNPLF PNARGLVPVA FFEVIGKNQR DSGDSVHAPV DLQQQQQQHH
HHQPRLAHDS GFSDSSNNNK TEEKASHFRM SSLGKAGAAA MVYGIVMYDF NAERPDELDA
KAGEAIIVIA QSNPEWFVAK PIGRLGGPGL IPVSFIEIRD MSTGKSAADP LEAVRRAGVP
RVEEWKKMTA EYKNSSISLG KFENGAQQAA AELERMNLNS RSNVHQRNPS KGYPQQQHQQ
QQHYQVPIPV QASIPRYCFD NDKYWYIVEV QMEDGRWWEL SRYYHDFYDF QIALLSKFEE
EAGNRGGQRT LPFMPGPVTQ VTNAISNSRR QSLDEYVKQL LAMPPHISRC QLVRQLFAPR
PGDFEIDPTV MSDDYRLSTG SQQSSGHNPS RTASRQSSQG QMNAASQGYH PSQRPTHQRN
QGSISHQPQQ LLQQQQQQQQ PPPMSRQGSS FNSNSNQMPS QNPGAIKIKV FFQDDIIVIR
VPDDISLRQL IDKLRDRLKV DAMVVRYKDE PSNSFVELLN DADLETAIRR NAKLMLYVST
V
//
