ID C5FGZ0_ARTOC Unreviewed; 525 AA.
AC C5FGZ0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Mch2p {ECO:0000313|EMBL:EEQ28620.1};
GN ORFNames=MCYG_01439 {ECO:0000313|EMBL:EEQ28620.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ28620.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family.
CC {ECO:0000256|ARBA:ARBA00006727}.
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DR EMBL; DS995702; EEQ28620.1; -; Genomic_DNA.
DR RefSeq; XP_002848505.1; XM_002848459.1.
DR AlphaFoldDB; C5FGZ0; -.
DR STRING; 554155.C5FGZ0; -.
DR GeneID; 9230643; -.
DR VEuPathDB; FungiDB:MCYG_01439; -.
DR eggNOG; KOG2504; Eukaryota.
DR HOGENOM; CLU_001265_1_2_1; -.
DR OMA; AWCNGSI; -.
DR OrthoDB; 1386626at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17352; MFS_MCT_SLC16; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11360; MONOCARBOXYLATE TRANSPORTER; 1.
DR PANTHER; PTHR11360:SF324; TRANSPORTER (MCH2), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12260)-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 56347 MW; 50798939DE336231 CRC64;
MENDPAVYSS NGPASHQVEK EANYSGEKGP GRNSIPRSDE DLNEKETEDI PPDGGYGWVC
VLCAGLINAN TWGVNSSYGV FLSYYLENGI FPNTSPIEYA FTGGLSMSCC LLISPLVTHM
VHLYGNRAVL NFGVILQTLS FIGASFATQK WHIFLSQGVC FGFGIGVIFV TSVSIIPQWF
RRKRSIANSL AAAGSGIGGL SYSLAAGSLI PKVGLGWTFR VLGLCSFAMN LIASNLMRDR
NKAIGSRYRA FHFPLLNRPE FLFLQAWGML SLLGYVVILF SLPNFALSIG LSQKQGSIAG
ALLNLGQALG RPVVGLVSDR YGRFNMAVLF TFFCGFLCLA VWIPSSNMVV LSFFAIIVGT
VAGTFWTTIV PVCAEVVGMQ ELPGGLSLTW VAMVPATTVA EPIALVLRHG SGSTGSYTYA
QVFTGIVYVA AGLFLLVVRG WKIGDNERIA KAAVNSNSGE ASSGRVFTTA PTAAMDDPIT
GCATVVPVMS RPDNDPRYPS TSSVVEVKLW SPLPLARRMV AWKLV
//
