ID C5FI77_ARTOC Unreviewed; 1412 AA.
AC C5FI77;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=5'-3' exoribonuclease 1 {ECO:0000256|PIRNR:PIRNR006743};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR006743};
GN ORFNames=MCYG_01876 {ECO:0000313|EMBL:EEQ29057.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ29057.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Multifunctional protein that exhibits several independent
CC functions at different levels of the cellular processes. 5'-3'
CC exonuclease component of the nonsense-mediated mRNA decay (NMD) which
CC is a highly conserved mRNA degradation pathway, an RNA surveillance
CC system whose role is to identify and rid cells of mRNA with premature
CC termination codons and thus prevents accumulation of potentially
CC harmful truncated proteins. {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR006743}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family.
CC {ECO:0000256|PIRNR:PIRNR006743}.
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DR EMBL; DS995702; EEQ29057.1; -; Genomic_DNA.
DR RefSeq; XP_002848942.1; XM_002848896.1.
DR STRING; 554155.C5FI77; -.
DR GeneID; 9228993; -.
DR VEuPathDB; FungiDB:MCYG_01876; -.
DR eggNOG; KOG2045; Eukaryota.
DR HOGENOM; CLU_001581_1_2_1; -.
DR OMA; VASWPWF; -.
DR OrthoDB; 167745at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF83; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR006743};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR006743};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR006743};
KW Nonsense-mediated mRNA decay {ECO:0000256|PIRNR:PIRNR006743};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR006743};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR006743}.
FT DOMAIN 1..202
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 258..657
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 706..893
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 897..1120
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1138..1208
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1221..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1314..1329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1412 AA; 159242 MW; 19FFE8C5E969EFF5 CRC64;
MGVPKFFRWL SERYPAISQL IAENRIPEFD CLYLDMNGII HNCTHKDSDS PAFRMTEDKM
FIAIFNYIEH LFGKIKPKRL FFMAIDGVAP RAKMNQQRAR RFRTALDAEL AKEKAIREGV
EMPKEDAFDS NCITPGTEFM TKLTKQLRYF INKKVSEDAE WQGVEVVLSG HEVPGEGEHK
IMEYIRQAKA QPEYDPNMRH CFTISLCSRE SDVWTAEPEE IKELEHQNFY LLHLCIVREY
LELEFQELKL DGALQFPFDM ERVIDDFILM AFFVGNDFLP NLPNLHINEG ALAWMFKVYK
EVLPKLGGYV NEHGKINMER LRTLLAALSD VEFRFFEAEY SDARWLKSKT LGGDQTPTLP
DKPNVLTVTP AQKHIFNRIK KYVTHRPMDE SGHPVPLDLS PSLPAKDRKF VEQLADSLHL
KWSSVLDNHD ERFLRLQLPV NSDDDDDDDD DDGESQIAIL RVLKKYENAK VQETTAEDAQ
LTAEKKYEKK FQEWKDKYYK EKFGWGLENT EEMRKLTENY VQGLQWVLFY YYRGVASWPW
FYRYHYAPMI SDIHLGLGAD VEFKLGQPFF PFQQLMGVLP DRSKKIVPVA YHSLMTTPES
PIIDFYPRDF ELDMNGKKME WEAVVKIPFI DEERLLKAMA TKEHLLTPDE KARNTFGVTL
KFTYSPDVEF IYPSSLPGIF PDVSRCHCIE NVFELPTMEG LDPYVGLVEG VKIGAEALAG
FPSLQTLQQT GQLGFHGVCV FQQESRNESM VVTIVDPEIA GNTTDAKAKL GRRVHVGYPF
LQEAKVVCVS DELFDYVQVD DEEHVVAIPH TPTQINQWKK KAEKIESYYS KRLGMIIGEV
ETIVRVEMLK GLMKTADGAT VKEFTEIPGV ETEYAAQLIV DSVISEDLRF IERAAVPIEE
EFPEGARAFF LGEYNYGAPV HVTGHEDGKL SGLLSAVKGK EPEFGREHVM NAEKLSKYTP
SFAIARNLHL SPLTLAKITS SFSVNVDGTR VNLGLNLKFE AKKLKVLGYS RRGNSGWEFS
ERAIGLLQDY MIKFPDFIAG IQRKPQGDLF EPTDFYPADI AKQKIKEIQS WLKSIESKSF
ERVPLEAEQL DSSIVQAIEK SADELHQTRA APVAQKIRGV PRNALLKPAD AEHRLNNQHF
QLGDRVIYAQ DSGKVPIASR GTVVGLTRTS RNLLLDVLFD VSFMSGTTLS DRCSPFRGST
VPSSSVLNLT NRQLVALSRA TAQNKEHARE QQPSKGAKYG APQGSGGMGQ LKDASTPPPL
TNSYRGAAIG QPSNSKVNGT PNLNWRGRGR GTLPIRNHPA HADTTGQPRP LFNRGRGNFN
QTNAHTGNGP SGRGRGRGGY VNVESMNTDS GVLNHNPDFK PRPYNTVPPP ASLNQPTGQR
GSAGRARGRG MARGGRGRAR AGHAGARGTT TA
//
