ID C5FMK8_ARTOC Unreviewed; 1021 AA.
AC C5FMK8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Na(+)/H(+) antiporter 1 {ECO:0000313|EMBL:EEQ31111.1};
GN ORFNames=MCYG_03930 {ECO:0000313|EMBL:EEQ31111.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ31111.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC {ECO:0000256|ARBA:ARBA00005248}.
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DR EMBL; DS995703; EEQ31111.1; -; Genomic_DNA.
DR RefSeq; XP_002848424.1; XM_002848378.1.
DR AlphaFoldDB; C5FMK8; -.
DR STRING; 554155.C5FMK8; -.
DR GeneID; 9229748; -.
DR VEuPathDB; FungiDB:MCYG_03930; -.
DR eggNOG; KOG4505; Eukaryota.
DR HOGENOM; CLU_008635_0_0_1; -.
DR OMA; PISWGNV; -.
DR OrthoDB; 1607026at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:InterPro.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR CDD; cd06174; MFS; 1.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR013928; Cation/H_antiporter_C.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR31382; NA(+)/H(+) ANTIPORTER; 1.
DR PANTHER; PTHR31382:SF4; NA(+)_H(+) ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF08619; Nha1_C; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..433
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 458..925
FT /note="Alkali metal cation/H+ antiporter Nha1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08619"
FT REGION 481..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..706
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..747
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..866
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..933
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 112336 MW; E28A1090503BF57F CRC64;
MAWDHLDIDK PHLAYMILGG FTSLFMLCSL FVKEKLYIGE ATVATLCGVI FGPHAANLFN
PISWGNVDKL TLECSRIVLV VQCFAVGVEL PKSYMERHWR SVVMLLLPIM TAGWLVTSLF
IWWMIEPLTW LESLICAACV TATDPVLASS VVGKGKFAKR VPKHLRDVLS AESGCNDGMA
FPFIYLSLYL MAYRNDTSKV AEHWILTTIL YECIFGAIFG FLIGYAGRHA IRFAENKKLI
DRESFLVFYF VLALFCAGAG SSLGMDDLLI GFSAGIGFSN DGWFTEKTEE SHVSNVIDLL
LNLTYFVYFG AIIPWEQYNL PDLGLVPWRL VVLAILVICF RRIPAMLMMK PLIPDIKTWR
EALFAGHFGP VGVGAIFACI LARAELENHS AQPLADIPQP GSKDYLIIYV IWPITTFLVI
SSILVHGSSV AVFTLGKHIN TLTLTMSYTQ AHEDGPSWMN RLPKIQSTSK SSLSIRKDSW
ELEKPEFPPG TLGPIGVPGN LLRRQRDDDH YSAPPSRASS RRPSRRHKQG AGGPISQSAI
TPQRRPEGET HVSKPPTPEP EALEDPRERR QHSEGGNTNM PEAEVYQEGN DFIVEDEEGN
VLEPDKVIKG KPGHNKLSST DEGETMRGFM KKFSSWAGFG NAQKDESHPQ INRSRRSARA
YQFANTIIVE DEDGEVIKKY TIPSSPKKTT ETGAEAEEDR PKLLRRLTKL GTWTGDAGNE
SSEAAKKAEE EEDAGIRFTV PVSDDVQHHL RGRRMSKQDF INQMQHLGPK SPTDGSSKLG
NIFRRDGNRG QAQPYHDTPT KIPEAPHEGA EGAPSPQEIS AMLSQYTAPE GSAADRRRRI
LSAPGSLASS FSRHDSEDDG TERIPPAHRR AIAAGQQSPS SNSPALPSGR NSKHVSKLDN
EIETPAERKR RLAALGVQHD SDSEDDGEPR VVKGKVQFAD GTRPAKKKSP MQQNVPKSSG
ALLPDSPAAP PAVYAPEDNP FSDNGAVPGS ASRSINEAGG NGTETTPRNN SKISWGGEIG
R
//
