ID   C5FQU8_ARTOC            Unreviewed;       479 AA.
AC   C5FQU8;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE            EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN   ORFNames=MCYG_05070 {ECO:0000313|EMBL:EEQ32251.1};
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ32251.1, ECO:0000313|Proteomes:UP000002035};
RN   [1] {ECO:0000313|Proteomes:UP000002035}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR   EMBL; DS995705; EEQ32251.1; -; Genomic_DNA.
DR   RefSeq; XP_002845201.1; XM_002845155.1.
DR   AlphaFoldDB; C5FQU8; -.
DR   STRING; 554155.C5FQU8; -.
DR   GeneID; 9225921; -.
DR   VEuPathDB; FungiDB:MCYG_05070; -.
DR   eggNOG; KOG1684; Eukaryota.
DR   HOGENOM; CLU_009834_22_0_1; -.
DR   OMA; EWEKSDM; -.
DR   OrthoDB; 3639304at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR   CDD; cd06558; crotonase-like; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EEQ32251.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002035}.
FT   DOMAIN          46..390
FT                   /note="Enoyl-CoA hydratase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF16113"
SQ   SEQUENCE   479 AA;  52937 MW;  38711FB4A1437EBF CRC64;
     MPLRAKVESS AFSGKARMLS SAAPVGPKEL PGDEPDDVLF SKLNGVRLVE LNRPKKLNSL
     NGSMVRKILP RLQEWEKSQL ANIVMISGAG TKAFCAGGDV AELAKQNTLG VSGQKKSREF
     FGQEYQLDHY IATYSKPYVA VLDGITMGGG VGLSVHAPFR IATEHTMFAM PETTIGFFPD
     VGGSFFLPRL DGEIGTYLAL TSERLSGVQA FYAGIATHYL PSSALGNLTN RLSELVFSDY
     ASLNSRLDLI NKTISEYAVS IPTLKEEPML LAGSLRESID RCFAHSTMEE IISALEKETV
     NADWAAKTLK TLAQRSPIAL KVTLRQLRVG KNWSISETFQ REDQIAGHFM AHPDFVEGVS
     ARLVNKPPTA PVWKHGSLAE VTDADVDEFF RIPKGESRLP LLNKNADYKQ YPHAKFALPQ
     EHSILQFVEK NKPTRSQVVE EFMKRTDAKL GVKEKVYEVL KRKTKETDEG LVLIEEGQS
//