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Entry: C5FXT4_ARTOC
LinkDB: C5FXT4_ARTOC
Original site: C5FXT4_ARTOC 
ID   C5FXT4_ARTOC            Unreviewed;       295 AA.
AC   C5FXT4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit {ECO:0000256|ARBA:ARBA00014912};
GN   ORFNames=MCYG_07943 {ECO:0000313|EMBL:EEQ35124.1};
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ35124.1, ECO:0000313|Proteomes:UP000002035};
RN   [1] {ECO:0000313|Proteomes:UP000002035}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The SRB8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC       phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC       RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC   -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC       Mediator complex. {ECO:0000256|ARBA:ARBA00011612}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000256|ARBA:ARBA00008638}.
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DR   EMBL; DS995707; EEQ35124.1; -; Genomic_DNA.
DR   RefSeq; XP_002844160.1; XM_002844114.1.
DR   AlphaFoldDB; C5FXT4; -.
DR   STRING; 554155.C5FXT4; -.
DR   GeneID; 9230875; -.
DR   VEuPathDB; FungiDB:MCYG_07943; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   HOGENOM; CLU_034754_2_0_1; -.
DR   OMA; TTCQTVI; -.
DR   OrthoDB; 102875at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd20513; CYCLIN_CCNC_rpt1; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10026; CYCLIN; 1.
DR   PANTHER; PTHR10026:SF7; CYCLIN-C; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF028758; Cyclin, C/H/G types; 2.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
PE   3: Inferred from homology;
KW   Cyclin {ECO:0000256|RuleBase:RU000383};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   DOMAIN          53..142
FT                   /note="Cyclin-like"
FT                   /evidence="ECO:0000259|SMART:SM00385"
SQ   SEQUENCE   295 AA;  33170 MW;  DE1113650C30D412 CRC64;
     MAANYWNSTQ RRFWLFDREK LAETRAALEE ADRAFIAQYP LPDHRLVNIY INQQLIKLGK
     RMNTRQQALA TAQVYVKRFF TKVSIRRTNP YLLLTTAFYL ACKTEECPQH IKYVVSEARG
     LWPEFILSDA AKVGECEFWL ISELNSQLII HHPYRTLSDF SSTLTNTSST GLVLSSDEIA
     LAWSVVNDSY LTDLPLLQPP HVIAVMAVFV AVVFKPGTAG SSTSAGMAAG IREGMGDGGR
     VQKVVEWLAG SEVSIEAVVD CTQEMVALYE VWEGYGEKGL REAIGRYVRG RFLDK
//
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