ID C5FXT4_ARTOC Unreviewed; 295 AA.
AC C5FXT4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit {ECO:0000256|ARBA:ARBA00014912};
GN ORFNames=MCYG_07943 {ECO:0000313|EMBL:EEQ35124.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ35124.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex. The SRB8-11 complex
CC phosphorylates the C-terminal domain (CTD) of the largest subunit of
CC RNA polymerase II. {ECO:0000256|ARBA:ARBA00025278}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, a regulatory module of the
CC Mediator complex. {ECO:0000256|ARBA:ARBA00011612}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000256|ARBA:ARBA00008638}.
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DR EMBL; DS995707; EEQ35124.1; -; Genomic_DNA.
DR RefSeq; XP_002844160.1; XM_002844114.1.
DR AlphaFoldDB; C5FXT4; -.
DR STRING; 554155.C5FXT4; -.
DR GeneID; 9230875; -.
DR VEuPathDB; FungiDB:MCYG_07943; -.
DR eggNOG; KOG0794; Eukaryota.
DR HOGENOM; CLU_034754_2_0_1; -.
DR OMA; TTCQTVI; -.
DR OrthoDB; 102875at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20513; CYCLIN_CCNC_rpt1; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF7; CYCLIN-C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF028758; Cyclin, C/H/G types; 2.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 53..142
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
SQ SEQUENCE 295 AA; 33170 MW; DE1113650C30D412 CRC64;
MAANYWNSTQ RRFWLFDREK LAETRAALEE ADRAFIAQYP LPDHRLVNIY INQQLIKLGK
RMNTRQQALA TAQVYVKRFF TKVSIRRTNP YLLLTTAFYL ACKTEECPQH IKYVVSEARG
LWPEFILSDA AKVGECEFWL ISELNSQLII HHPYRTLSDF SSTLTNTSST GLVLSSDEIA
LAWSVVNDSY LTDLPLLQPP HVIAVMAVFV AVVFKPGTAG SSTSAGMAAG IREGMGDGGR
VQKVVEWLAG SEVSIEAVVD CTQEMVALYE VWEGYGEKGL REAIGRYVRG RFLDK
//