ID C5KYU7_PERM5 Unreviewed; 338 AA.
AC C5KYU7;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Thiolproteinase SmTP1, putative {ECO:0000313|EMBL:EER10345.1};
GN ORFNames=Pmar_PMAR014310 {ECO:0000313|EMBL:EER10345.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER10345.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; GG677539; EER10345.1; -; Genomic_DNA.
DR RefSeq; XP_002778550.1; XM_002778504.1.
DR AlphaFoldDB; C5KYU7; -.
DR EnsemblProtists; EER10345; EER10345; Pmar_PMAR014310.
DR GeneID; 9038103; -.
DR InParanoid; C5KYU7; -.
DR OMA; HEQWMAD; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..338
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012226460"
FT DOMAIN 26..80
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 118..336
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 338 AA; 37497 MW; 93BE00DB6530041B CRC64;
MLTPILLSSI LGVFSEQTPL EVQNLFEAYK DEYDHDFGEE DANRLAIFHD NLKFIDEVNS
RNLSYKLGIT PFTHLTNDEF REFVTRGYSL GDWQQTMLRG IDSEAQTFGF EGSVDDDLPM
RVDYVEKGWV TDVKFQGTVC GSCWAFGVAG ALEGLHKNVT GQLVSLSEQE LIDCSRAYGN
NGCNGTRHLN DSYEYVADHG LETERAYKYV GKDGQCRRDV CEYAIKAGTI SHVNVKSNSS
SSMLAAVAFG GPVSAVSCAW AGVFQNYKSG IIKGGECGNL PSHVVLVVGY DRGHDPYYRI
KNSWGVQWGE HGYARLAIDD TDYGVCGILY EPVYPISK
//
