ID C5L1J7_PERM5 Unreviewed; 1027 AA.
AC C5L1J7;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=CSC1/OSCA1-like cytosolic domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Pmar_PMAR025979 {ECO:0000313|EMBL:EER09424.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER09424.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; GG678316; EER09424.1; -; Genomic_DNA.
DR RefSeq; XP_002777608.1; XM_002777562.1.
DR AlphaFoldDB; C5L1J7; -.
DR EnsemblProtists; EER09424; EER09424; Pmar_PMAR025979.
DR GeneID; 9052305; -.
DR InParanoid; C5L1J7; -.
DR OMA; DPTQVIW; -.
DR OrthoDB; 71979at2759; -.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF98; TO DEHYDRATION PROTEIN, PUTATIVE, EXPRESSED-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 15..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..703
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..168
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 188..293
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 425..700
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT COILED 293..328
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1027 AA; 114801 MW; 1A309A5D0FEE6098 CRC64;
MSSSSSGSSK TTTSMAVLIS FGIYIGIFAG MVLAYCLVKH KAPKLYNCRD NIPELRCPLS
DRKTGKWSWI RDAVLTSDDD LMRYAGLDAA AFIRLLKMGI KISLVGCFNS IFLIPIYKYQ
DRNDGSNESD TMQSWSLGNL LNGDSAMIAT LLASYLFYGY SMYLIYHEFS WYLRRRHEFL
ARKSLENYTI FVRGLPQELR SNQALRNFFE EVAPGKVLDA RVALDIDDLE KQEADRSKII
PKLEHAYNVA EYEGERPEMK IKMCGKEKMD TITVLERRLA ALNRYCEKTV RSAEDFQEKA
DELFREQLEE KEKREEEAER GLSKQLINLT KAPVNIVKDV ADIVPLPKAL MPTNLLPFGE
KPAFQTRSDG FVTFRSLKAS MSALQMVHSA TPFKLYAMPA PLPDDVFWDN VGVPHMRQEL
GMLLSISLTV VLCVFWTVPV AFVSSVSQVQ NLKRELPFLE TWSEAWPGID VLLQQISPIL
LSVLNSLLVV FLKLFSQLEG HISNSTLSAS LFAKLAAFYI IQTFFVSAIA GSLLASLHEL
SVDPWGTIQD ILGNNLPQQA NYFMSFVFVQ VGPPLGSELL RYTPLIKALV RKNIGPRLTE
KERSQAFFGL EPLSNPVTLD QPKLLSTVML FFMILFVYAV TSPFVSFVMA FAFACEAVIY
KNQYAFIYDP SNDSGGQMWT RAMRFIIFCE IVAEITVMAV LAIKEGAVAS PLMIPLFIAT
ILFWLYLEQQ HFRVAVYLPS RTCVEVDSAR DKLAEIDFDA WFGAYRQEAL KVVYEVNVKC
RDKETAERFF GWLVNQGHVA EVVKNEGFSS AEVFTDVEDA RKLVARYVVD SVEDLDAYSS
GPGVVKEIAL KKEGIEKFGS EQQVVSFTPL TMISEKSINT SKLMSMLDEG SNLEDECAKL
RSSVIRCTSK HSANFYIRAV QNFLKGMPAK GELPAKMPID RVQVTGLAAA ITYAVAAATA
TQSAGVGKIV SIKTGVVMVQ PDRPVGRSAA EEHGVPSISI VIERVVDSGE DAMKKEEAAG
EPVKKSD
//
