ID C5LBP1_PERM5 Unreviewed; 4345 AA.
AC C5LBP1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Dynein-1-alpha heavy chain, flagellar inner arm I1 complex, putative {ECO:0000313|EMBL:EER05862.1};
GN ORFNames=Pmar_PMAR011916 {ECO:0000313|EMBL:EER05862.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER05862.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG680918; EER05862.1; -; Genomic_DNA.
DR RefSeq; XP_002774046.1; XM_002774000.1.
DR EnsemblProtists; EER05862; EER05862; Pmar_PMAR011916.
DR GeneID; 9064591; -.
DR InParanoid; C5LBP1; -.
DR OMA; LHCHFGE; -.
DR OrthoDB; 275566at2759; -.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF343; DYNEIN AXONEMAL HEAVY CHAIN 10; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW Cell projection {ECO:0000313|EMBL:EER05862.1};
KW Cilium {ECO:0000313|EMBL:EER05862.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Flagellum {ECO:0000313|EMBL:EER05862.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007800}.
FT DOMAIN 291..604
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 619..771
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1278..1690
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1825..1900
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1904..1979
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2204..2273
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2494..2588
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2644..2899
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2913..3252
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3281..3501
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3750..3863
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3894..4040
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4047..4341
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 150..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1095..1153
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3127..3203
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 159..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4345 AA; 493258 MW; 1AAFD17F982654AE CRC64;
MVPGEGPSVG TDSRGLWLLR KMKELIYITD DEWKDMLSEA ETGSRIIHWL DGKGGRGDLL
VFYNVLSEAG HKSLHVSVGM HEVEKAISVM GKLVAGMYFI RTASGKIDTA GKEVNVAMLS
SCIFGVLGDT RILYDVQIVM EQLFLPALDY KPPDGSSPGR NRKSLTESHI SSRGLSLPEA
GTDMMSVMSS VMEGSSEDED SDASEKSAES KEEKPDGREN GGDARLVQVG SETRDELVLN
ASKFHQKLGQ VASQVYGSSS IRPPEGVDLD ELLRKLEGSE ECGEDVLRCV EAVGQWAEEV
ERLLKTEKEH ATAIGPHPMA EILFWRDRSE RLSSLFEQLQ LGRCQKVGTF LCGGGSASRI
QVIEIQSALH KLHVEAKDNV RFLMTLERHL KKLTNGGMAE IAEMLPNLMN ALRMVWVVSR
YYNTDERMEP LLQRIAEQIA TRVSDQISVK YLLRRSPVRA GVLVAQCKAT LEGWEKHYME
TRSRIEESGS DHRWEFDRAK LFKRTKYMAK TCGDLMVITK MLEQFYKFLG PELKEVTGDA
VGIDKLLDEV TTAAAAFKAY SECFDDRHRK AWEREMKLFK EKTIEIEDKA IVFLDTRFRQ
VNLAQEDFVG VSSTCFGTGQ KACGDYVELG KAILKYERDL FGEWRKSASL TATECLNRSI
LAIEKHEGRA SASYMVNLAP ELIELMKEAQ NFDLIGGFEL PAAIVNLALQ MDKYEDYAEK
LRIMLQSYEE AVEGLTMVQC KVLQSQIADL HKALRPGLTP LNWNSLGIAD FIESATRGIA
AFKNIREQVE KSEERVEAVV ESIEQSILDS FESSSDGEDI MDIQEFYDYF ENHRISEVEK
LVEQYESIGP FLIKIEETAT GTKSGAAECM KEYYTYWERR VYNAITTALI RGLSTFQVLL
TATTQRPPLI RMRAEFNPPE VVVGSLHGVF KLLSKLMQNI LLSSSAFMRW MDGTCLLVPA
QTAEQDEEKA IMFTFHKDVS QNAALIEMTM NIQNSLQQVF QVINKFMRSW KKYDTQWGLW
DMRRRQDLER VVNEKKPGLS YFEVHLKVYK NLVDTMLSHK RDQDVAFVRI DCIAVITGIR
TQAQEWLADY GRILSDSASK ELERIRAEIK EFKDNIDFNP TKLEELKLML STISSIEASN
MDMEIRIADL QEKYRTLASY KCMVKTEEKS LAEGLPSAWR NLKKYSRAKD LALEKSKIEF
AETTKQEVKA FGEECRKLLD NFSVRGPDTY DVTLDEGVEL MRKYQNELNH GLKKKEELVK
SEMLFNLPIT SYVELVILER QLKLVKNVYD IYEDHRKMVE EFSNMLWTKI DIGMLERTSD
EYEKKVRKRG KDLPELKSSA IFKKLEQVVS DFKQSVPLIA SLKTDAIRPS HWGELMALAG
QVPEDAEDEE AAAADIDLAS MTLRSVFALE LQRFPEEVNE IRTTAINEMN IENELKRIEA
AWRALNLDMG IYKGDRGHVL RGNEELKQTL EDHVLVLQSM GMSKYAMKLM DSIKRWEKNL
NIVNEVLNAW LTVQRKWMYL ESIFLDSDDI RLQLPEEAKK FDKIHKVFKE LMERTAASPN
AIQACCGNDR LNELKGLTAE LDRTQKSLTD YLDTKRALFP RFYFISDDEL LSILGSSDPQ
AVQPHSLKLF DNAKEIVFKP GTATVIGMVS DEGERWTFCT PVKAVGAVEE WMTKVDEEMK
DSLLRLMKEA VYHYPSTPRT EWILSRLGMV VLAGTQTWWT WSIEDTFKRV MEKGDKNAMK
RELRKESHEL GQLVELIRTN LSSCNRKCVN TLIILDVHAR DIVDRFVRDS ILDAREFAWE
SQLRFMWDRK LDDILIKQCT GSFRYCYEYQ GLNGRLVITP LTDRCVMTLT TALTFLLGGS
PAGPAGTGKT ETVKDLAKSL AIRCVVFNCG EGLDFKAMGK DEGTTLQGLL SDLFPGLECP
RVGYPTLKKA IEEELESRSM KHRYEDLYAL QVDKIMQLYE TMLTRHTTMV VGKTMSGKSA
VIECLAGAQK RAFDTPTHLY PINPKMVTVN ELYGVLDPAT RDWTDGLLSK IFRDINQPIP
AGKGEEKRYI LYDGDVDAVW VENMNSVMDD NKILTLNNGE RIRLEKHCAM LFEVDNLQYA
SPATISRCGM VYVDDKDLGP GPFYDRWARG KGDKVEKILM EMFEKWVRPC LALLCDGRVD
GEVLADGPLA GSLPRSQVGT DYVVQLSKIF DSIVGGEVGH MKPLTVASVF VFTMVWSLGS
VLEERTREQF DEFLKMVVKK HEIPGIDSIE LPKESLYEML YNTTGEAWVP WEERVMEYEE
GSPDRDFNSI LVPTVDTTRY SWLRSQFAKV KAPCLFVGES GTAKSVTIIN SLEADPVETS
LMLLINFSSR TSSADFQRNI EDNIFKRTGR VFGPEQGKTL RIFVDDLSMP KIDKYGTQQP
LALLKFVVEK GFMYERGGDL ERIVIQDIEY IAAMQPPGAG RNSIDPRVVS LYCAIGITFP
STETIDKIYS SILRGMFVLF GDEVREMALR LPEVTLLLHR KVVENMPRSP SKFHYIFNLR
DLSRVYQGVC QGDPQVVTTG AKLVRLWRHE FTRVYADRLI DSSEREYVEE ELLGAVIETK
FPECQEEVLR EPLVFGDFKD VIGILEADEP TGEVRLYEDM RDWEAVNRIL LAVLELYNSD
RSGMNLVLFV DAMRHMARIH RILRLPQGNA LLVGIGGLGK QSLTKLASFA AEQELYEIAL
CRGYGDSNLK EDLKALYQVA VKKPQTFLFT DANVVEEGFL EYINNMLTVG MVPALFADDE
KESLISGVRS KAKAEGVSES RMWTYCVNHI RSQLHMVLAM SPAGSALRVR CRNFPGLVTC
TTIDWFEPWP NDALLAVATQ LLAECDIPAE NREDINHFIC EAHLSVTTKY SPDFEAKFKR
RNFATPKNYL DFLSGYEDLL AKNRKTIDAQ TQRLGGGLDK LVQAAEQVTI MSKDLAAKKV
IVDEKALAVG TLIEEINEKS MTVSKHQKVA NEQAKQIADD NVIIQREKED ADTALAEALP
ALEMAAKALE ELDKKDITEI KSMASPPAPV MTVCQCVLIL RPLGREDENG GWAAAKQMLS
DVSLLRALQV YKKDDMKDRQ IKKIKELLAK DKDVFEGDNM KNISKAGFGL LQWVKAMIKY
HEVARTVEPK RKLVAELTQK KEEAEANLER INEELRTLAE NIERLSKEEV EQSAVLKSLE
EEAEAMQRKL EAASKLIDGL ASERKRWSTD ITLQGDKKVR LVGDCLLGSA FISYAGPFNH
QFRNEMLYGD WLGRVVEADI PTSRDFKLEA LLTSDVEVTL WSSQGLPSDE LSVQNGILTT
RTNRFPLCVD PQMQAVTWLK KKEERTNGGL TVKTFNDEYI KYLELAIQYG KPFLFENLDE
EIDPMIDPVL EKRYVIQNGQ KLLTLGDNTI EWSDTFVLFM TTRISNPRYS PEIMGKVSII
NYTVTLDGLA AQLLNVVVGF ERPDLQAERQ QLVQSMSENR QVIKNLEDTL LRELAASKGS
ILDNEELIQT LQTAKTKALE ITEALETAAR TSVEIDNMRE IYSEVAKRGS ILYFATQGLS
AISEMYEYSL GSYLAVFEQA LREAKPDKII DNRLKNVREK LTQNVYDFTC MGLFERHKLL
FSFQMTCMIM DGEKELVMQD HEFFLKGNPS LEKVAIPNPH PDWLPDAGWK DMQVLPSLGE
CFENIIDDVS SAEGGKLWKT WFDLEQPESS PMPMGYDESC DPFQQLLVVR CLRTDRVVNA
IKNFIMWRLG EYYVQPPSLV YDKIFQQSNE KSPIVFILSP GADPQSDVQQ LGEKLGFTAP
SKFRFLALGQ GMGPVAQSSI ETGYHRGHWV MLQNCHLLTR WLRTLESILE GMTKPHSDFR
LWLTTQPTQA FPLGILQRSL KVVTEPPDGL KLNMKQSYAK ITDADLDECT HEAFKPLIFV
LAFFHAVVQD RRKYGSIGWN VPYDFNESDF KISFQLLRLY IDKAQESDDP LPWETMRYLI
GEAMYGGRVT DNYDRRVLCT YLEEYMGDFI FDENQDFFFS RSGHDYTVPK GRLDVEAYVA
SIGALPITQS PAVFGLHPNA EITYFSNSAK DLWLGVLCMQ AGDTSGGGGM SRESFIQQTT
RDIIAAIPKK DMKFLKNEGS LTPTEVVLSQ EIDRFNALAN SMYESLIDLG RALVGEIGMS
NELDELGTSI FNGFLPSHWA RLAPRSEKPL GSWMDHFRRR LEQYGRWMAE GDPHVMWLAG
LHVPESLLSA LVQAASRKRG WPLDKSTLYT QVTGMMSPEE VTEPLAFGTY VEGLYLEGAR
WDISLGELAR QNPKQLVVLM PLIQIIPVEA GRLKLRESLP TPVYLTPKRR DAMGNGFVFE
ANLRTREHPS VWILQGVALF LNTDQ
//
