ID   C5LH95_PERM5            Unreviewed;       191 AA.
AC   C5LH95;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   03-MAY-2023, entry version 32.
DE   RecName: Full=tRNA-uridine aminocarboxypropyltransferase {ECO:0000256|ARBA:ARBA00012386};
DE            EC=2.5.1.25 {ECO:0000256|ARBA:ARBA00012386};
GN   ORFNames=Pmar_PMAR017318 {ECO:0000313|EMBL:EER03904.1};
OS   Perkinsus marinus (strain ATCC 50983 / TXsc).
OC   Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC   Perkinsus.
OX   NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN   [1] {ECO:0000313|EMBL:EER03904.1, ECO:0000313|Proteomes:UP000007800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA   El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-
CC         amino-3-carboxypropyl]uridine in tRNA + H(+) + S-methyl-5'-
CC         thioadenosine; Xref=Rhea:RHEA:62432, Rhea:RHEA-COMP:13339, Rhea:RHEA-
CC         COMP:16092, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:82930; EC=2.5.1.25;
CC         Evidence={ECO:0000256|ARBA:ARBA00024168};
CC   -!- SIMILARITY: Belongs to the TDD superfamily. DTWD2 family.
CC       {ECO:0000256|ARBA:ARBA00034489}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG682011; EER03904.1; -; Genomic_DNA.
DR   RefSeq; XP_002772088.1; XM_002772042.1.
DR   AlphaFoldDB; C5LH95; -.
DR   EnsemblProtists; EER03904; EER03904; Pmar_PMAR017318.
DR   GeneID; 9044500; -.
DR   InParanoid; C5LH95; -.
DR   OrthoDB; 206884at2759; -.
DR   Proteomes; UP000007800; Unassembled WGS sequence.
DR   GO; GO:0016432; F:tRNA-uridine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR005636; DTW.
DR   InterPro; IPR039262; DTWD2/TAPT.
DR   PANTHER; PTHR21392:SF0; TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2; 1.
DR   PANTHER; PTHR21392; UNCHARACTERIZED; 1.
DR   Pfam; PF03942; DTW; 1.
DR   SMART; SM01144; DTW; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          3..167
FT                   /note="DTW"
FT                   /evidence="ECO:0000259|SMART:SM01144"
SQ   SEQUENCE   191 AA;  21601 MW;  8D06E80BDD1A2238 CRC64;
     MHPSERKRKN RTVDLVATKC LRGVHVVVGR RILADTLPID SPLQAVLKNP EECALIYPTE
     DAETVHAQHS GDSKIRHLIF LDATWKYAKE MYASSPPLVA LKHKWVLKPD KEGAFVIRKE
     PLANAGLLST AEAIAFALDA LSTDHSRLPV VREVLTRFSE IQISRTEHVI HHREKKNYVE
     NLYDLGERSA K
//