ID C5LRU4_PERM5 Unreviewed; 382 AA.
AC C5LRU4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Mucolipin, putative {ECO:0000313|EMBL:EER00550.1};
GN ORFNames=Pmar_PMAR011309 {ECO:0000313|EMBL:EER00550.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER00550.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG684970; EER00550.1; -; Genomic_DNA.
DR RefSeq; XP_002767832.1; XM_002767786.1.
DR AlphaFoldDB; C5LRU4; -.
DR EnsemblProtists; EER00550; EER00550; Pmar_PMAR011309.
DR GeneID; 9043625; -.
DR InParanoid; C5LRU4; -.
DR OrthoDB; 276868at2759; -.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF7; SD02261P; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 133..263
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 346..373
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 382 AA; 42741 MW; 61A92FBF8C32B391 CRC64;
MVEVNPEPSR IENSSGRMQR GAHREEDLIP ADWHLYWKSG RFKPSEYATV ESTWAIWALL
TMLVCALASA AVNVLALGYR IKVIHTFLKD SSVQDKLTVM NLWLLFSLIG NIIQLVAVGY
AFLVDRPDIY MRLNLFGVSA AIALVSLVRY LAHFRSLYIL YSTLAHGIPQ IFKFLVGVFP
VYLSFVVCAV CLFGFHSHWF VSLGDSSTAL FSLLNGDQIH DTFTNLKDVS VLGSRVFLYS
FLALFIYVVL NIFITIAEDA FFTVKFMQGG AGTITNIPCY RHQAPAVHFL HNNTEEITRM
PKSLTSYRHR ASDPLLRKLA ALDESGVMVS HDEASTVAGG DSPPNQHELQ AQVALLMRQC
VEMQDQVRKL SEALLSKGSS RV
//
