ID   C5LWX1_PERM5            Unreviewed;       472 AA.
AC   C5LWX1;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE            EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN   ORFNames=Pmar_PMAR027233 {ECO:0000313|EMBL:EEQ98749.1};
OS   Perkinsus marinus (strain ATCC 50983 / TXsc).
OC   Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC   Perkinsus.
OX   NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN   [1] {ECO:0000313|EMBL:EEQ98749.1, ECO:0000313|Proteomes:UP000007800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA   El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC         EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR   EMBL; GG686286; EEQ98749.1; -; Genomic_DNA.
DR   RefSeq; XP_002766032.1; XM_002765986.1.
DR   AlphaFoldDB; C5LWX1; -.
DR   EnsemblProtists; EEQ98749; EEQ98749; Pmar_PMAR027233.
DR   GeneID; 9062760; -.
DR   InParanoid; C5LWX1; -.
DR   OMA; NYKTLMT; -.
DR   OrthoDB; 340883at2759; -.
DR   Proteomes; UP000007800; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.200.40; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR   PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR   PROSITE; PS50146; DAGK; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EEQ98749.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW   Transferase {ECO:0000313|EMBL:EEQ98749.1}.
FT   DOMAIN          104..259
FT                   /note="DAGKc"
FT                   /evidence="ECO:0000259|PROSITE:PS50146"
SQ   SEQUENCE   472 AA;  51988 MW;  D5804AB85F3DB74D CRC64;
     MDLLADFFKS HFGYRSKPRG KQGAELEDAL VVLEDESIVV RAVTSGRVYD ALLFEDVVAV
     NYGDSSLEIT VLEIRQKGCT CSAGRQRRDI VLERFDRWEE TQCPTKTRAL VIINPASGKG
     DALDLYTNKA KPLLDLCQDR FIVQEVVSES AEHTREVAVE SAGNFDAFIF CGGDGLVHDF
     LQAIFKLPHY RDILHRVTLG FLPGGSGNGL ACSCAYATED CDNMAVDPKA IVGDFQVALR
     LILRGKTSPL DAAVFDVLDR ETRECKVTLL ASLNAAFGLF SDVDLGSEHL RFLGDTRFHV
     YALWRIISLR KYAARVSYIE ACDLPHGQQL LESLPDESSP LWQYAEEGEF AGVTLSNLSH
     MGPGMMIAPG RKLGDGSWTM CWLPYKSSSF GTLVKGLTKM EMGTHTEMSH LWKEKSVVAW
     KIEPANKQSE ITGEGATVDG EAVPRGILCG YVLPRLMNVY ASQGSVVQSD GH
//