ID   C5LX81_PERM5            Unreviewed;       820 AA.
AC   C5LX81;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=Pmar_PMAR016864 {ECO:0000313|EMBL:EEQ98630.1};
OS   Perkinsus marinus (strain ATCC 50983 / TXsc).
OC   Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC   Perkinsus.
OX   NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN   [1] {ECO:0000313|EMBL:EEQ98630.1, ECO:0000313|Proteomes:UP000007800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA   El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GG686414; EEQ98630.1; -; Genomic_DNA.
DR   RefSeq; XP_002765913.1; XM_002765867.1.
DR   AlphaFoldDB; C5LX81; -.
DR   EnsemblProtists; EEQ98630; EEQ98630; Pmar_PMAR016864.
DR   GeneID; 9062338; -.
DR   InParanoid; C5LX81; -.
DR   OMA; FYLWFFL; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000007800; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        402..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        447..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        536..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        562..583
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        634..654
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        756..779
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
SQ   SEQUENCE   820 AA;  93236 MW;  145D45E616E005C7 CRC64;
     MGILRSELMT HGTVVLPHEY ARNYVDLLGK QTKVMFEDMN SAVMQRPYRK YIQRIEDMER
     MLRVLDSEIA KMPDVTLYKN RIDDFLDHDD EFTLDTLEAE IKRVYEQFIR FRGNNEDLTA
     ELDSATEELN VVQNSLSSGS VAAGTGAALE APLLQGEPTA RGTGRERMGM QFSNIAGVVK
     MEDQESFART VFRATRGNTF TQFTEIPDTR KSVFVIYFQG AAANSYMSAK LHRICGAVGV
     HLYQWPATHD EARVRINELQ SIIADKTHAL AGFDRFIRDE ARGLVEPIRV GGNSRIEEWK
     LFCIKERNIY ATLNLFEGDV TLRCDCWYPS KEEDSIRRVL GESELAASAM LVADIAKPRA
     APPTYTKTNE FTAAFQALVD TYGIPRYQEF NAGVVSIITF PFMFGIMYGD VGHGTLITCF
     ALWALSNAKK WKYSDDGMQQ GLVYARYLLL FMGLFAIYAG CMYNDLLGVG IHWFGTARYE
     DPAEYGHASN YEMKPKAWFD TLNTGEGSGP YPFGIDPSWH GATNELLFMN SLKMKLSVLF
     GVFQMIFGVC IKFGNDAYMR EWIDFIFVAI PQMVFLLGFF GYMDWMIMYK WVTPVTQDPT
     LNGAPSLINT LISFGLGQAD KQPLFLAQPA VQKWLMLAVV ISVPVMLLPK PIIIQIQRSI
     RNKKNNRNAV ANDDVEAQAL ITKESETDEE LEEEGMDEVW IYQMIETIEY VLGCVSHTAS
     YLRLWALSLA HQQLSVVFFQ MIMQGALQST SWASPIFIYC AFAVLFGITL GVLMFMDVLE
     CFLHTWRLHW VEFQSKFYMG DGYSFVPFCH FDIIKDELQA
//