ID C5M368_CANTT Unreviewed; 723 AA.
AC C5M368;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Vacuolar transporter chaperone 4 {ECO:0000313|EMBL:EER35768.1};
GN ORFNames=CTRG_00507 {ECO:0000313|EMBL:EER35768.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER35768.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER35768.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
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DR EMBL; GG692395; EER35768.1; -; Genomic_DNA.
DR RefSeq; XP_002545726.1; XM_002545680.1.
DR AlphaFoldDB; C5M368; -.
DR STRING; 294747.C5M368; -.
DR EnsemblFungi; CTRG_00507-t43_1; CTRG_00507-t43_1-p1; CTRG_00507.
DR GeneID; 8298413; -.
DR KEGG; ctp:CTRG_00507; -.
DR VEuPathDB; FungiDB:CTRG_00507; -.
DR eggNOG; KOG1161; Eukaryota.
DR eggNOG; KOG4580; Eukaryota.
DR HOGENOM; CLU_009308_0_0_1; -.
DR OrthoDB; 11387at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033254; C:vacuolar transporter chaperone complex; IEA:EnsemblFungi.
DR GO; GO:0005516; F:calmodulin binding; IEA:EnsemblFungi.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IEA:EnsemblFungi.
DR GO; GO:0008976; F:polyphosphate kinase activity; IEA:EnsemblFungi.
DR GO; GO:0016237; P:microautophagy; IEA:EnsemblFungi.
DR GO; GO:0006799; P:polyphosphate biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0007034; P:vacuolar transport; IEA:EnsemblFungi.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; IEA:EnsemblFungi.
DR CDD; cd07751; PolyPPase_VTC4_like; 1.
DR CDD; cd14480; SPX_VTC2_like; 1.
DR Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR InterPro; IPR003807; DUF202.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR018966; VTC_domain.
DR InterPro; IPR042267; VTC_sf.
DR PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR PANTHER; PTHR46140:SF1; VACUOLAR TRANSPORTER CHAPERONE 4; 1.
DR Pfam; PF02656; DUF202; 1.
DR Pfam; PF03105; SPX; 1.
DR Pfam; PF09359; VTC; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 633..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..678
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..156
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 505..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 84244 MW; 10020E0D515E965C CRC64;
MKFGEHLRKS LIKNYSFYYI AYDDLKHQLK KGLYDNDGTW NDDLEESFLN SLENELDKVY
SFTKVKNTEV TRRIKDSETY VYEVVDALHR YQNHDPAITT PPSEEDFQEL QDELSDIIAD
VHELNKFANL NYSGFYKIIK KHDKVTGYSL RPIFQARLNH KAFYKDNYDA LIVKLSKLYD
LVRTRGNPVQ GDSSAGGSQQ NFVRQTTKYW VHPDNITELK LIILKHLPVL VFNPDKEFET
EDSAITSIYF DNKDMDLYYG RLRKDEGAEA IRLRWYGGMK TEQIFVERKT HREDWTGEKS
VKARFGLKEK QVNSFLSGEL TANQVFEKAR KQGKKSPQEI DNLERLAKEV QYRVLKEKYR
PVMRSFYNRT AFQLPGDARV RISLDTELTM VREDDFDGYD RTQGNWRRMD IGVDYPFSQL
PEKDVCRFPY AVLEVKLQTQ LGQEPPVWIR ELVASHLVEA VPKFSKFIHG GATLLTDHVD
LLPFWYTQMD VDIRKPKTQS EIGIQRNTPA RIERSSTSGN DLDEEELTGS SYTTGVHFSN
DYNPLEDDLD ENTPLLLPNT YSSRHSSSPV RNFLYHWYGR FLHFFNDDRT FTVKPGTNWD
LNATFKDKLP KGKTICVPVR IEPKVYFANE RTFLSWLSMG MLLGAVATTL LNYGSKSALT
SSIGFFITAI FTIAYSTYKY LWRVLMIREK KVTAYGDKFG PNMICAFIFL ATFVTFLFKY
SEH
//
