ID C5M3F5_CANTT Unreviewed; 553 AA.
AC C5M3F5;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Cyclin-like domain-containing protein {ECO:0000259|SMART:SM00385};
GN ORFNames=CTRG_00594 {ECO:0000313|EMBL:EER35855.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER35855.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER35855.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TFIIB family.
CC {ECO:0000256|ARBA:ARBA00010857}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG692395; EER35855.1; -; Genomic_DNA.
DR RefSeq; XP_002545813.1; XM_002545767.1.
DR AlphaFoldDB; C5M3F5; -.
DR STRING; 294747.C5M3F5; -.
DR EnsemblFungi; CTRG_00594-t43_1; CTRG_00594-t43_1-p1; CTRG_00594.
DR GeneID; 8296107; -.
DR KEGG; ctp:CTRG_00594; -.
DR VEuPathDB; FungiDB:CTRG_00594; -.
DR eggNOG; KOG1598; Eukaryota.
DR HOGENOM; CLU_010293_3_3_1; -.
DR OrthoDB; 5483352at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000126; C:transcription factor TFIIIB complex; IEA:EnsemblFungi.
DR GO; GO:0000994; F:RNA polymerase III core binding; IEA:EnsemblFungi.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; IEA:EnsemblFungi.
DR GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IEA:EnsemblFungi.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:EnsemblFungi.
DR GO; GO:0001156; F:TFIIIC-class transcription factor complex binding; IEA:EnsemblFungi.
DR GO; GO:0001112; P:DNA-templated transcription open complex formation; IEA:EnsemblFungi.
DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; IEA:EnsemblFungi.
DR GO; GO:0070898; P:RNA polymerase III preinitiation complex assembly; IEA:EnsemblFungi.
DR CDD; cd20553; CYCLIN_TFIIIB90_rpt1; 1.
DR CDD; cd20554; CYCLIN_TFIIIB90_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR Gene3D; 1.20.5.650; Single helix bin; 1.
DR InterPro; IPR011665; BRF1_TBP-bd_dom.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR023486; TFIIB_CS.
DR InterPro; IPR013150; TFIIB_cyclin.
DR PANTHER; PTHR11618:SF4; TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT; 1.
DR PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1.
DR Pfam; PF07741; BRF1; 1.
DR Pfam; PF00382; TFIIB; 2.
DR PRINTS; PR00685; TIFACTORIIB.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS00782; TFIIB; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 93..174
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 188..272
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 474..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 62267 MW; 590A06C3BF67281F CRC64;
MSRPRKERKC KNCGYTQFDV NRYTAAGDVC CLRCGTVTEE NPIVSEVQFG ESSSGAAMVQ
GAMVGADQAR ATFAGGRQNA MESREQTINT GKRRIKRIAA AMKIPDYIAD AAAEWFRLAL
TLNFVQGRRS HNVLATCLYV ACRKERTHHM LIDFSSRLQI SVYSLGATFL KMVKALHITS
LPLADPSLFI QHFVEKLDFK DKATKVAKDA VKLAHRMAAD WIHEGRRPAG IAGACVLLAA
RMNNFRRSHA EIVAVSHVGE ETLQRRLNEF KKTKAGQLSI KSFREVEHLE SSNPPSFEKN
RAMELKIAKK LQQQQQDTFE GLTKITEANG DDIPLKKVDK EELQKQILLN TILSDITITS
DTLNEQMDRI LKMKKTSLEN SLYKTPYELS NSQESDLDKI WDMNRPRNLV KNLPKTDEIL
EKVSSEMELN SDDDDEIVME SKLTEEEIAI KERIWTGLNH DYMVEQEKKR LKMEADELTG
NTSNSSGGNR RKKNKNSLPP ELRKDFGDIE LDEDGTPRSA ADSAKRYIAK TSVSKKINYD
SLKGLLGGGM GLN
//
