ID C5M4E1_CANTT Unreviewed; 518 AA.
AC C5M4E1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN ORFNames=CTRG_00931 {ECO:0000313|EMBL:EER36191.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER36191.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER36191.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 1/5. {ECO:0000256|ARBA:ARBA00004873}.
CC -!- SIMILARITY: Belongs to the anthranilate synthase component I family.
CC {ECO:0000256|ARBA:ARBA00009562}.
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DR EMBL; GG692395; EER36191.1; -; Genomic_DNA.
DR RefSeq; XP_002546149.1; XM_002546103.1.
DR AlphaFoldDB; C5M4E1; -.
DR STRING; 294747.C5M4E1; -.
DR EnsemblFungi; CTRG_00931-t43_1; CTRG_00931-t43_1-p1; CTRG_00931.
DR GeneID; 8298259; -.
DR KEGG; ctp:CTRG_00931; -.
DR VEuPathDB; FungiDB:CTRG_00931; -.
DR eggNOG; KOG1223; Eukaryota.
DR HOGENOM; CLU_006493_9_3_1; -.
DR OrthoDB; 705at2759; -.
DR UniPathway; UPA00035; UER00040.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005950; C:anthranilate synthase complex; IEA:EnsemblFungi.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:EnsemblFungi.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR005256; Anth_synth_I_PabB.
DR InterPro; IPR015890; Chorismate_C.
DR NCBIfam; TIGR00564; trpE_most; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF9; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT DOMAIN 41..179
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 239..494
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 518 AA; 58297 MW; F2289E119651C923 CRC64;
MQSQSVQPTI DTLKKIIDTN NSLSDSPNVY PVYKYVPHND ITIHQAYLKL SKLNDPKRTE
SFLFESSIKG DTVDRYSFIG IKPTKIIKTG DDENKYPKGF CNVDPITVLE KELLNYKQAE
LPGLPKFSGG ATGYISYDCI KYFEPKTKRP MKDVLGLPEA VLMFCDLVIA FDHVFQRFQI
IYNIKIDEDN GSLEELYNQA TAKIDEVEKI LLTEVSNEEI APKQGPIKLG QNFTSNIGQE
GYEQHVTTLK KHILKGDIIQ AVPSQRIARP TSLHPFNIYR HLRTVNPSPY LFYIDLLDFQ
IIGASPELLV QSDAKGRIVT HPIAGTMPRG KTNEEDEKNA EILRASLKDR AEHIMLVDLA
RNDVNRVCQP TTNSVDKLLT IQRFSHVMHL VSEVSGTLRE DQTRFDAFRS IFPAGTVSGA
PKVKAMELIA ELEKEKRGVY AGAVGHWGYD GKTMDTCIAL RTMVYKDGIA YLQAGGGIVY
DSNEYDEYVE TLNKMKANNN TIVEAEKIWA DKVGSTEV
//
