ID C5M6G4_CANTT Unreviewed; 370 AA.
AC C5M6G4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Translation initiation factor eIF2B subunit beta {ECO:0000256|ARBA:ARBA00044122};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit beta {ECO:0000256|ARBA:ARBA00044228};
GN ORFNames=CTRG_01445 {ECO:0000313|EMBL:EER34584.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER34584.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER34584.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; GG692396; EER34584.1; -; Genomic_DNA.
DR RefSeq; XP_002547139.1; XM_002547093.1.
DR AlphaFoldDB; C5M6G4; -.
DR STRING; 294747.C5M6G4; -.
DR EnsemblFungi; CTRG_01445-t43_1; CTRG_01445-t43_1-p1; CTRG_01445.
DR GeneID; 8301333; -.
DR KEGG; ctp:CTRG_01445; -.
DR VEuPathDB; FungiDB:CTRG_01445; -.
DR eggNOG; KOG1465; Eukaryota.
DR HOGENOM; CLU_016218_4_3_1; -.
DR OrthoDB; 169494at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IEA:EnsemblFungi.
DR GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:EnsemblFungi.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IEA:EnsemblFungi.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:EnsemblFungi.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR45859; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR PANTHER; PTHR45859:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000313|EMBL:EER34584.1};
KW Protein biosynthesis {ECO:0000313|EMBL:EER34584.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037}.
SQ SEQUENCE 370 AA; 41098 MW; C10E8B800E53284B CRC64;
MSLITPEISA LIDPVVSTLK RHQVEGHKEI ALTIAQLLMK VISAARWSNI YDLIELIRQV
GVIIHNAYPR KVISDNVVRR VLALIRDEIE PEQPTATTNT NTTTTENNPM MSSMFSLLST
NNNKNESIKE QKQPQSKKQT SDMRSIIIQG IRDLIDEISN VNEGIENMAV DLIHDGEVLL
TPTPSSDTVI HFLIQASAKR KFSVVVTENY PNEIKAAHKF VKTLAKHNIE TILIPDTTTY
AIMSRVGKVI IGTNAVFANG GCLSSSGVAN VVECAKEHRT PVFAVAGLYK LSPLYPFTSN
DLIEVGNAGK VLNYDDFQLV ENVDVVTNPL EDYIPPQHID IFMTNIGGFA PSFIYRVVLD
NYKPEDNKLE
//
