ID C5M7Z6_CANTT Unreviewed; 1841 AA.
AC C5M7Z6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=CTRG_02518 {ECO:0000313|EMBL:EER33700.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER33700.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER33700.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
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DR EMBL; GG692397; EER33700.1; -; Genomic_DNA.
DR RefSeq; XP_002548221.1; XM_002548175.1.
DR STRING; 294747.C5M7Z6; -.
DR EnsemblFungi; CTRG_02518-t43_1; CTRG_02518-t43_1-p1; CTRG_02518.
DR GeneID; 8299111; -.
DR KEGG; ctp:CTRG_02518; -.
DR VEuPathDB; FungiDB:CTRG_02518; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_3_1_1; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037}.
FT DOMAIN 139..289
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 481..646
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 748..796
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 981..1043
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1841 AA; 210994 MW; 8B11E320697D08FF CRC64;
MDFFMPRAIR SFEITLKTYL RRLLDFASDK EVFDIDVKNY AIKSVLSSIM LTFAGDSPHD
SRINFEKAII NANIVPDVDV PSGSIFDHFI SLPDCEWLEW NNKVSGVELE PHQVSNPNTI
VPTLDTVKHE NLVYSILNEH SPLLLCGPPG SGKTMTLFEA LRKSPQLELL SLNFSKETSP
LSLLKSLDQY CEYRKTNRGV QLTPRINGKW VVVFCDEINL PQVDKYGNQN VISLIRQMIE
HNGFWRVKDN QWVTLENIQF VGACNSPKDP GRNRLSDRFL RHVPVIMVDY PGHTSMLQIY
QTFNLAILKC APDLRGYAKA ITDASIQVYE KTKERFNSSI QKHYVYSPRE LTRWSRGLLE
ALKSSEYKDL HSFVRLWYHE GLRLFYDRLV SEDEKRWTLE LFAEVAQEFF PNVDLISCFK
EPVFFSNWMS LNYKSVGEKE LRSFVSQRLR VFSEEEMEVD LVLHDEMLDH ALRIDRVLRQ
PQGHMILVGP SGSGKSTLSK FVAWINGLKV VFLNVRTNYT IENFDSTLRQ ILTRCVNGER
ICFIIDESSI LEASFIERMN TLLANAEIPG LFEGDDYTAL MNNCLEISHS QGLLLDTEAE
LYNWFAQQIS QNLHVVFSIS DSTESNSQSV ISSPALFNRC VLSWMGDWSN KCLYEVASAR
IGVLPVDISN YAVPNSFTPY LPKRATNLRD IIADVLSYIH RFVPDYRSTL CYERTPNDYL
NLVHIFSKLF TKKQQELEDN QRHITVGLDK LRETVIQVDK LKNELAQKEE TLKVKDKEAK
QMLNKLLTDQ NEAERKQEFS IDAQAELEKQ EAEIQRRKEI VMKDLEYAEP AVLEAQRGVQ
NIKKQHLSEI RSMANPPAAV KMTMESVCIL LGYNVSSWRD VQLVIRKDDF IPNIVSFNGE
DQLSVELREY MEKVYLARED YTFELVHRAS KACGPLLQWV QAQLAYARIL QSVGPLREEV
QHLEQQTLKT KAQLIAVDQM IFELEESIEK YKESYSELIR ETENIKREMA SVHKKVDRSM
ALIKNLTKER ERWKESVSTF SAKRDKLVGE SVLVAGFIVY AGLYDQKGRE LLLRNWKNKL
QDAGIPYDEA LTIGNYLASS KEILHWVNSG LINDNLNIEN FALLKWSDNP VIIDPSATIV
DIVAKSTASK SVTVTSFLND GLLNQLENAL RFGGLMIIQD CEYYDPIVDN ILRKEVHRNG
GRTMIKLGDQ IVDYSSDFKL VLCSKESQLV LPPSVSSRTT VVNFTVTSGS LENRALDIAL
QEVRPDVEQQ RAELVILNGE WKLRLQALEE ELLNSLGTTA GELLDNDSVM ETLETLKIET
DGLNEKLAHS VEVMNHVEET RAKYQDVARG LSTIYSIFES LGGINHFYNF SLSRVIKNFS
ELLRRNLDSN PTDLIVNLYK DSFARVASSL QYQDKIVLAL VLTAAYYVES IGDIFKSAFI
RMLETIIADV DFEKSVGQIL DMCLARKEDG WNMENIIELN QDNSTLQILS KLMLLLATGD
VAQKSEFVDS FSQITSVLFE KDSTPYTSSY DLPYWINEYG VNVVILTCPD VFDASYKVEQ
ISSQKQKPLS IVSMGSKEGV QVANKELEKA ATSEKWILIQ NIQMSPAWLS QLENKLSNLH
SGTRVFLTCK NNSKVPIGLI SRCKVLNFEN EVGIKQIVWE TYKLICMSNK DKLQKHVLLL
LIWYHSVLVE RLRYVPVSYK KKYDFNDSDF TCGVSLIEKI FANYDGKPES IPWKEIRYLI
GTITYGGKVD NHKDLEFMKK LAEDIFTEKS FNSDFNLVAN KFTLENNEKL LLPDSQDDIE
SWINNLPYET PLSWIYLPMN ANTLVKKQMG LEIVEKVLDI V
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