ID C5MD77_CANTT Unreviewed; 705 AA.
AC C5MD77;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=CTRG_04178 {ECO:0000313|EMBL:EER32507.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER32507.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER32507.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; GG692399; EER32507.1; -; Genomic_DNA.
DR RefSeq; XP_002549881.1; XM_002549835.1.
DR AlphaFoldDB; C5MD77; -.
DR STRING; 294747.C5MD77; -.
DR EnsemblFungi; CTRG_04178-t43_1; CTRG_04178-t43_1-p1; CTRG_04178.
DR GeneID; 8299442; -.
DR KEGG; ctp:CTRG_04178; -.
DR VEuPathDB; FungiDB:CTRG_04178; -.
DR eggNOG; KOG1803; Eukaryota.
DR HOGENOM; CLU_001666_8_2_1; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 2.40.30.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR004483; SMUBP-2/Hcs1-like.
DR InterPro; IPR048761; SMUBP-2_HCS1_1B.
DR NCBIfam; TIGR00376; IGHMBP2 family helicase; 1.
DR PANTHER; PTHR43788:SF19; DNA-BINDING PROTEIN SMUBP-2; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF21138; SMUBP-2_HCS1_1B; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037}.
FT DOMAIN 234..491
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|SMART:SM00487"
FT DOMAIN 252..457
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 362..389
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 705 AA; 80026 MW; CA146E900DB54E7F CRC64;
MRSNYNKIAL ISRNKVQTFF FFYRSTNTYI KTMRLYDKFK TAIIEEQQED VEQTTTYINT
FTPKKLAQLG LGIINLQIAN IRTGLGGKTI LELQLDPGFS ATDEINTSTL RTGDIVRLSR
MSSSKPDKKS KKDGEESTSD GIDAVVLKVT TQAISISVDE ANDDSKVLQY YNNTNDQNSR
MWLVKLANSI TYKRMLMSMD KVNALEDKND IHRILLGESK YIPKPTSNLK LEFINDRLND
SQKEAIDFAI NKSNITIIHG PPGTGKTYTL IELIQQLTNN LGEKVLVCGP SNISVDTILE
RLHDKYKKPE KLIRMGHPAR LLPGNLAHSL EILSKSYGHD VIKDIEKDIQ STLSQIKKCK
RYAERKALYQ ELKLLRKELK QREKKIVAEL LQQSQVVIST LHGAGSFDLK GVSFDTIIID
EVSQSLEPQC WIPLLLTSNF KRLVIAGDNM QLPPTIKCKK NESFLGTTLF DRLVKQCDGD
SFRKLLNVQY RMNQSIMEFP SMQLYDNKLL CDSSVKDISL LDLPGVEDNE TTSAKCIWYD
TQGGEFPEQI NESIEGGDSK YNEMEILVVQ GHLQKLLDSG VRPQDIGIIS PYAAQVQLLK
KKVVPEVEVH TVDGFQGREK EVIILSLVRS NDDREIGFLS EQRRLNVAIT RPKRHLCIVG
DLELLNQGGQ GSNSFLRKWC KYVEDGEGEE PYEIEYPNLT DYLEN
//
