ID C5MFM0_CANTT Unreviewed; 302 AA.
AC C5MFM0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=DNA replication complex GINS protein PSF1 {ECO:0000256|ARBA:ARBA00015143, ECO:0000256|RuleBase:RU368085};
GN ORFNames=CTRG_04863 {ECO:0000313|EMBL:EER31133.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER31133.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER31133.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Required for correct functioning of the GINS complex, a
CC complex that plays an essential role in the initiation of DNA
CC replication, and progression of DNA replication forks. GINS complex
CC seems to bind preferentially to single-stranded DNA.
CC {ECO:0000256|RuleBase:RU368085}.
CC -!- SUBUNIT: Component of the GINS complex which is a heterotetramer of
CC SLD5, PSF1, PSF2 and PSF3. {ECO:0000256|ARBA:ARBA00011352}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU368085}.
CC -!- SIMILARITY: Belongs to the GINS1/PSF1 family.
CC {ECO:0000256|ARBA:ARBA00006677, ECO:0000256|RuleBase:RU368085}.
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DR EMBL; GG692401; EER31133.1; -; Genomic_DNA.
DR RefSeq; XP_002550565.1; XM_002550519.1.
DR AlphaFoldDB; C5MFM0; -.
DR STRING; 294747.C5MFM0; -.
DR EnsemblFungi; CTRG_04863-t43_1; CTRG_04863-t43_1-p1; CTRG_04863.
DR GeneID; 8298866; -.
DR KEGG; ctp:CTRG_04863; -.
DR VEuPathDB; FungiDB:CTRG_04863; -.
DR eggNOG; KOG3303; Eukaryota.
DR HOGENOM; CLU_079191_0_0_1; -.
DR OrthoDB; 166901at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0000811; C:GINS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd11710; GINS_A_psf1; 1.
DR CDD; cd21696; GINS_B_Psf1; 1.
DR Gene3D; 1.20.58.1030; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR005339; GINS_Psf1.
DR PANTHER; PTHR12914:SF2; DNA REPLICATION COMPLEX GINS PROTEIN PSF1; 1.
DR PANTHER; PTHR12914; PARTNER OF SLD5; 1.
DR Pfam; PF05916; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU368085};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368085};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037}.
FT DOMAIN 116..222
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
FT REGION 88..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 120..147
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 302 AA; 35036 MW; 2184332D5B12F4E6 CRC64;
MYGDIANKLI LDAKRSSNLS SIPIYQSELI RDIVKETNDL NKDADYLTEV HDEITNHLDT
LTEQYNDSLE KLQDINKQRV DLDKKLKEIE KKERDPRNSK DYTNEKNEIT GLDTVLAKRK
ETTANQAQEL SQEIEQINEK HSKINQCQLF VTHLSMRRNK RCLLAYEKLR ADKISEFAWL
NIDPIEGTPT STSLESNVNP ITKNLTGFTT SLDLNNLNHF EQDFFKQYQD LIMNFKSDFE
DIDLSGDLNP PTNIFIDVRV LKDGGEVTTE YGSFNLIKDS QFFVRKSDVE RLIQQGYLEE
IV
//
