ID C5MI21_CANTT Unreviewed; 1229 AA.
AC C5MI21;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Alpha-factor-transporting ATPase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CTRG_05714 {ECO:0000313|EMBL:EER30718.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER30718.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER30718.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG692403; EER30718.1; -; Genomic_DNA.
DR RefSeq; XP_002551416.1; XM_002551370.1.
DR AlphaFoldDB; C5MI21; -.
DR STRING; 294747.C5MI21; -.
DR EnsemblFungi; CTRG_05714-t43_1; CTRG_05714-t43_1-p1; CTRG_05714.
DR GeneID; 8300929; -.
DR KEGG; ctp:CTRG_05714; -.
DR VEuPathDB; FungiDB:CTRG_05714; -.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_000604_17_8_1; -.
DR OrthoDB; 1693178at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR GO; GO:0043332; C:mating projection tip; IEA:EnsemblFungi.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblFungi.
DR GO; GO:0015440; F:ABC-type peptide transporter activity; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000770; P:peptide pheromone export; IEA:EnsemblFungi.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03228; ABCC_MRP_Like; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR PANTHER; PTHR24221:SF503; LP14331P; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 783..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..332
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 364..599
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 664..951
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 986..1224
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1229 AA; 137785 MW; 13467FE6A26AB12D CRC64;
MKAEIDEKEP FPETDADNLE VDVSKNVFMF VELSKDWPII ILGVLLMAAS AAATPINTYV
YGKIMGQLSE FYINGSSYHL FINQIGRLCG VLIGVGGAKL ILVWMGMFIW LKFGEIQQHR
AREEIFDKIL KEPTSWYDLN TNLMGEMTQV NRCIEELRSG NGEIMANIVQ TCGLVISLII
MSFYQSWQIT LIVMASAPVM AVVGWYFGKL TYKAQEQENE YTSQASKILD WCLVNPISVR
IFNGKYIELS KFNHIVNTSA KSYYKVANAI AANSGVLKFL TLMMFVQGFW FGVYLMQKGR
VTIGQLFTTF SSTLMLGQTI SGVTSLLAVL NTSHAAAGKI AKYLQTEEEP QLATCYPSYS
VDNIEFDNVT FKYPSRDEII LKGVTFKIQQ NRFNYIIGKS GAGKSTIPLI IMNLYPTIGG
AVRIDGIPIQ YLDPKYIAQN ITLLQQNPVM FNNKTILENI ALGVIDDYDT LEDIPRHLVE
KAAKFSLLSD LDLDMKVSGS SLSGGQQQRI SIARAYLKDS PVLIMDESFS ALDNQNKQVL
FQRIKKWRNG KTTIFITHEY DNIEDDDFVI IMEHGNVKDQ GEFIKFKNDE VVTSYKAQAY
EEVKEPEVTK EKAHTNYDYK TNPYILKDLE SASIDEDKEE EKLMGVIAIL KYCSSSITRK
WLLALGVLIS LLEGAANPIF SYCFSKLLAI SMEASIGVNV TSKIVVWSCI SLSIAGFTGI
STYLSEFILQ YCSENWIVSL RQMSFDKINN QDMSYFNSKL EPAEITTLLM NDTRDLRSLV
SQYISLVTTL VTMVLIGVIW SIVTGWKLAL VGIAFVPLVL LVTCAYGIIL EIAENKYKTS
VVDVETQIHQ TMTSIKTIRL FHMNRYFKES YDEALVGLKS VGTYRAFQTG IGFAISDLCS
AISQGIILFY GMQLAGKFQY SYFQLLEVIT LLTFTISNAS SLINHLPDIA RGQRAGTFVV
KLLESTPISK VETEGKIIPR PSDKAISFNN VTFAYPSDLL EPKLKNVTFD ININETVGLV
GESGSGKSTI ISILLRLYGA KSVKLFNEDI SQIDIDWLRE TIGIVPQFPK FFDGSIYDNL
LYGMNPIRIV SEQEVTNVLK LVNMYEFIVS LPEGIQTCIG EGSNSLVSGG QLQRLSIARA
ILRNPKILIF DECTSNLDPI NSKQIIKLIE SLNGKFTILF ITHDKEMMRI ADNLIVLKNG
KLVEQGSYLQ LISSKGELSE ITKSPDIFL
//
