ID C5MIE6_CANTT Unreviewed; 255 AA.
AC C5MIE6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=rRNA methyltransferase 2, mitochondrial {ECO:0000256|ARBA:ARBA00041184};
GN ORFNames=CTRG_05839 {ECO:0000313|EMBL:EER30440.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER30440.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER30440.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase RlmE family.
CC {ECO:0000256|ARBA:ARBA00009258}.
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DR EMBL; GG692404; EER30440.1; -; Genomic_DNA.
DR RefSeq; XP_002546361.1; XM_002546315.1.
DR AlphaFoldDB; C5MIE6; -.
DR STRING; 294747.C5MIE6; -.
DR EnsemblFungi; CTRG_05839-t43_1; CTRG_05839-t43_1-p1; CTRG_05839.
DR GeneID; 8300188; -.
DR KEGG; ctp:CTRG_05839; -.
DR VEuPathDB; FungiDB:CTRG_05839; -.
DR eggNOG; KOG4589; Eukaryota.
DR HOGENOM; CLU_009422_4_0_1; -.
DR OrthoDB; 2785996at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_01547; RNA_methyltr_E; 1.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR015507; rRNA-MeTfrase_E.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10920; RIBOSOMAL RNA METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10920:SF18; RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF01728; FtsJ; 1.
DR PIRSF; PIRSF005461; 23S_rRNA_mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRSR:PIRSR005461-1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 46..240
FT /note="Ribosomal RNA methyltransferase FtsJ"
FT /evidence="ECO:0000259|Pfam:PF01728"
FT ACT_SITE 197
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005461-1"
SQ SEQUENCE 255 AA; 29121 MW; 2EF72812197666B9 CRC64;
MILFKLPHHI TAPIHFKRFK SDKSLKNYVN RVQGDSFVSQ RKTSLYKSRA AFKLEEIDDK
LHIFKNGTRN IVDLGFAPGA WTQVAVNRLE SKNLPYNILG VDINPASPVR GCHYIQGDVT
KKSTQTKILE FFKRCDVLDK ITFEEDEYKH IDLVMSDMMV NTTGSSVNDH YGSIYLCNAA
LHLAFHQLKP GKDFVVKIFN GSELDSFQAR LKLMFAQVHA VKPRASKDVS SELYLVGRKK
YDMKEKGITI EQLFG
//
